000 04179nam a22005295i 4500
001 978-90-481-9522-0
003 DE-He213
005 20140220084603.0
007 cr nn 008mamaa
008 101013s2010 ne | s |||| 0|eng d
020 _a9789048195220
_9978-90-481-9522-0
024 7 _a10.1007/978-90-481-9522-0
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aWu, Wen-Sheng.
_eeditor.
245 1 0 _aSignal Transduction in Cancer Metastasis
_h[electronic resource] /
_cedited by Wen-Sheng Wu, Chi-Tan Hu.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2010.
300 _aXII, 288 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v15
505 0 _aOverview of Signal Transduction in Tumor Metastasis -- Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways -- The ERK1/2 MAP Kinase Signaling Pathway in Tumor Progression and Metastasis -- Mitogen-Activated Protein Kinase-Activated Protein Kinases and Metastasis -- Grb2 and Other Adaptor Proteins in Tumor Metastasis -- The Role of ROS Signaling in Tumor Progression -- Signal Cross Talks for Sustained MAPK Activation and Cell Migration Mediated by Reactive Oxygen Species: The Involvement in Tumor Progression -- Insights into the Dynamics of Focal Adhesion Protein Trafficking in Invasive Cancer Cells and Clinical Implications -- Notch Signaling in Cancer Metastasis -- New Concepts on the Critical Functions of Cancer- and Metastasis-Initiating Cells in Treatment Resistance and Disease Relapse: Molecular Mechanisms, Signaling Transduction Elements and Novel Targeting Therapies -- Involvement of Lipid Rafts in Growth Factor Receptors-Mediated Signaling for Cancer Metastasis -- Cadherin-Catenin Signaling in Ovarian Cancer Progression -- PTP4A3, a Signal Molecule Deregulated in Uveal Melanoma Metastasis -- Signal Transduction Pathways Involved in Hepatocarcinogenesis and Metastasis of Hepatoma.
520 _aThe poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aCell receptors.
650 0 _aCytokines.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aMolecular Medicine.
650 2 4 _aCytokines and Growth Factors.
650 2 4 _aReceptors.
650 2 4 _aCell Biology.
700 1 _aHu, Chi-Tan.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048195213
830 0 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v15
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-9522-0
912 _aZDB-2-SBL
999 _c113661
_d113661