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001 978-90-481-9301-1
003 DE-He213
005 20140220084603.0
007 cr nn 008mamaa
008 100927s2010 ne | s |||| 0|eng d
020 _a9789048193011
_9978-90-481-9301-1
024 7 _a10.1007/978-90-481-9301-1
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aCarlier, Marie-France.
_eeditor.
245 1 0 _aActin-based Motility
_h[electronic resource] :
_bCellular, Molecular and Physical Aspects /
_cedited by Marie-France Carlier.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2010.
300 _aXII, 300p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aCellular Aspects -- Elementary Cellular Processes Driven by Actin Assembly: Lamellipodia and Filopodia -- Coupling Membrane Dynamics to Actin Polymerization -- Endocytic Control of Actin-based Motility -- Actin in Clathrin-Mediated Endocytosis -- Actin Cytoskeleton and the Dynamics of Immunological Synapse -- Actin-based Motile Processes in Tumor Cell Invasion -- Actin-based Chromosome Movements in Cell Division -- Roles for Actin Dynamics in Cell Movements During Development -- Molecular Aspects -- Regulation of the Cytoplasmic Actin Monomer Pool in Actin-based Motility -- From Molecules to Movement: In Vitro Reconstitution of Self-Organized Actin-based Motile Processes -- The WASP-Homology 2 Domain and Cytoskeleton Assembly -- Formin-Mediated Actin Assembly -- Visualization of Individual Actin Filament Assembly -- Movement of Cargo in Bacterial Cytoplasm: Bacterial Actin Dynamics Drives Plasmid Segregation -- Physical Aspects -- Protrusive Forces Generated by Dendritic Actin Networks During Cell Crawling -- Mathematical and Physical Modeling of Actin Dynamics in Motile Cells -- Force Production by Actin Assembly: Simplified Experimental Systems for a Thorough Modeling.
520 _aThis book presents the cellular, molecular and physical aspects of force and movement by the self-assembly of actin, one of the most abundant proteins found in cells, into cytoskeletal filaments. « Actin-based motile processes » are responsible for a large variety of motile activities such as chemotactic locomotion, embryonic and metastatic cell migration, wound healing, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic activities, as well as morphogenetic processes including, axis patterning in early embryos, axonal growth in brain development, and the immune response and synaptic plasticity processes at the origin of learning and memory. The book describes how the recently undertaken multidisciplinary and multiscale approaches have explored the molecular and physical mechanisms at the origin of force and movement produced by actin self-assembly. The chosen topics show how advances have been made in the field of cell motility due to the progress in live cell imaging, light microscopy, improved resolution in the structure of large protein assemblies, the biochemical analysis and mathematical modeling of actin assembly dynamics and the development of nanotechnologies enabling us to measure forces in the range of pico- to nano-newtons produced by actin assemblies.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aBiotechnology.
650 0 _aCytology.
650 0 _aDevelopmental biology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aCell Biology.
650 2 4 _aDevelopmental Biology.
650 2 4 _aBiotechnology.
650 2 4 _aCancer Research.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048193004
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-9301-1
912 _aZDB-2-SBL
999 _c113631
_d113631