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020 _a9789048190782
_9978-90-481-9078-2
024 7 _a10.1007/978-90-481-9078-2
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
100 1 _aWang, Xiaoyuan.
_eeditor.
245 1 0 _aEndotoxins: Structure, Function and Recognition
_h[electronic resource] /
_cedited by Xiaoyuan Wang, Peter J. Quinn.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2010.
300 _aXVII, 415p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v53
505 0 _aI Structure and Properties of Endotoxins -- Endotoxins: Lipopolysaccharides of Gram-Negative Bacteria -- Purification and Characterization of Lipopolysaccharides -- Endotoxins: Relationship Between Structure, Function, and Activity -- The Diversity of the Core Oligosaccharide in Lipopolysaccharides -- Salmonella-Regulated Lipopolysaccharide Modifications -- The Variation of O Antigens in Gram-Negative Bacteria -- Regulators of TLR4 Signaling by Endotoxins -- Membrane Partitioning: Is Location Everything When It Comes to Endotoxin Recognition? -- Infection, Treatment and Immunity -- Endotoxin Detection – from Limulus Amebocyte Lysate to Recombinant Factor C -- The Role of Endotoxin in Infection: Helicobacter pylori and Campylobacter jejuni -- The Role of Pseudomonas Lipopolysaccharide in Cystic Fibrosis Airway Infection -- Development of Small-Molecule Endotoxin Sequestering Agents -- Development of an Anti-Endotoxin Vaccine for Sepsis -- Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvants -- Targeting Endotoxin in the Treatment of Sepsis -- Lipopolysaccharides in Rhizobium-Legume Symbioses -- Lipopolysaccharides and Plant Innate Immunity.
520 _aEndotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMicrobiology.
650 0 _aToxicology.
650 0 _aEmerging infectious diseases.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
650 2 4 _aInfectious Diseases.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aImmunology.
700 1 _aQuinn, Peter J.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048190775
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v53
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-9078-2
912 _aZDB-2-SBL
999 _c113583
_d113583