000			02861nam a22005175i 4500
001			978-90-481-9057-7
003			DE-He213
005			20140220084602.0
007			cr nn 008mamaa
008			100907s2010 ne | s |||| 0|eng d
020			_a9789048190577 _9978-90-481-9057-7
024	7		_a10.1007/978-90-481-9057-7 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aShlaes, David M. _eauthor.
245	1	0	_aAntibiotics _h[electronic resource] : _bThe Perfect Storm / _cby David M. Shlaes.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2010.
300			_aCVI, 8p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_a1 The Perfect Storm -- 2 The Miracle -- 3 Resistance – The miracle is fading -- 4 The FDA – We need them, but they have become part of the problem -- 5 Europe -- 6 The Pharmaceutical Industry – after a glorious history, the industry is now struggling on all fronts -- 7 Modest Proposals -- 8 Conclusions.
520			_aAntibiotics are truly miracle drugs. As a class, they are one of the only ones that actually cure disease as opposed to most drugs that only help relieve symptoms or control disease. Because bacteria that cause serious disease in humans are becoming more and more resistant to the antibiotics we have today, and because they will ultimately become resistant to any antibiotic that we use for treatment or for anything else (like crops, animals, etc.), we need a steady supply of new antibiotics active against the resistant bacteria that arise. But the antibiotics marketplace is no longer attractive for large pharmaceutical companies, the costs of development are skyrocketing because of ever more stringent requirements by the regulatory agencies and finding new antibiotics active against resistant strains is getting harder and harder. These forces are all combining to deny us these miracle drugs when we need them the most. I provide a number of possible paths to shelter from this perfect storm.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aDrug interactions.
650		0	_aToxicology.
650		0	_aBiotechnology.
650		0	_aPharmacy.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aImmunology.
650	2	4	_aDrug Resistance.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aBiotechnology.
650	2	4	_aPharmacy.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789048190560
856	4	0	_uhttp://dx.doi.org/10.1007/978-90-481-9057-7
912			_aZDB-2-SBL
999			_c113580 _d113580