000 03974nam a22004575i 4500
001 978-90-481-3465-6
003 DE-He213
005 20140220084558.0
007 cr nn 008mamaa
008 100301s2010 ne | s |||| 0|eng d
020 _a9789048134656
_9978-90-481-3465-6
024 7 _a10.1007/978-90-481-3465-6
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aWolf, Norman S.
_eeditor.
245 1 4 _aThe Comparative Biology of Aging
_h[electronic resource] /
_cedited by Norman S. Wolf.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2010.
300 _aVIII, 388p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction: Lifespans and Pathologies Present at Death in Laboratory Animals -- Animal Size, Metabolic Rate, and Survival, Among and Within Species -- Hormonal Influences on Aging and Lifespan -- Exploring Mechanisms of Aging Retardation by Caloric Restriction: Studies in Model Organisms and Mammals -- Cell Replication Rates In Vivo and In Vitro and Wound Healing as Affected by Animal Age, Diet, and Species -- Sirtuin Function in Longevity -- The Role of TOR Signaling in Aging -- Mitochondria, Oxidative Damage and Longevity: What Can Comparative Biology Teach Us? -- Comparative Genomics of Aging -- Changes in Lysosomes and Their Autophagic Function in Aging: The Comparative Biology of Lysosomal Function -- Telomeres and Telomerase -- Cardiac Aging -- Comparative Skeletal Muscle Aging -- Aging of the Nervous System -- Aging of the Immune System Across Different Species.
520 _aCover copy: Wolf, Norman (ed.), The Comparative Biology of Aging The processes of aging and death remain one of the most fascinating, and mysterious, areas of biological research. Huge anomalies between species raise questions the answers to which could have fundamental implications for the field of medical science. As scientists unlock the secrets of the exceptionally long-lived little brown bat (up to 34 years), or the common Budgerigar which despite having a metabolic rate 1.5 times that of a laboratory mouse, can live for up to 20 years, it has become more important than ever to be able to make a comparative analysis of the various species used in research. Dealing with every one of the species that are employed in laboratory research, this is the first book on the subject of aging that provides detailed comparative data for age-related changes in its subjects. It does so at the level of the whole animal, its organs, organelles and molecules. The comparative data, supplied in 15 chapters by leading experts, provides information on fields as disparate as telomere function and loss, the importance of the Sirtuins and Tor, the influence of hormones on lifespans, the relationship between body size and lifespan, the effects of restricted calorific intake, age-related changes in cell replication, and DNA damage and repair. Chapters are devoted to cardiac aging, comparative skeletal muscle aging, the aging of the nervous and immune systems, the comparative biology of lyosomal function and how it is affected by age, and many other key areas of research. This much-needed text will provide scientists working in a wide spectrum of fields with key data to aid them in their studies.
650 0 _aMedicine.
650 0 _aGeriatrics.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aGeriatrics/Gerontology.
650 2 4 _aOxidative Stress.
650 2 4 _aCell Physiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048134649
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-3465-6
912 _aZDB-2-SBL
999 _c113355
_d113355