000 04458nam a22005415i 4500
001 978-90-481-3435-9
003 DE-He213
005 20140220084558.0
007 cr nn 008mamaa
008 100427s2010 ne | s |||| 0|eng d
020 _a9789048134359
_9978-90-481-3435-9
024 7 _a10.1007/978-90-481-3435-9
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aGerasimovskaya, Evgenia.
_eeditor.
245 1 0 _aExtracellular ATP and Adenosine as Regulators of Endothelial Cell Function
_h[electronic resource] :
_bImplications for Health and Disease /
_cedited by Evgenia Gerasimovskaya, Elzbieta Kaczmarek.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2010.
300 _aXI, 300p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPurinergic and Pyriminergic Activation of the Endothelium in Regulation of Tissue Perfusion -- Nucleotides and Novel Signaling Pathways in Endothelial Cells: Possible Roles in Angiogenesis, Endothelial Dysfunction and Diabetes Mellitus -- Extracellular Purines in Endothelial Cell Barrier Regulation -- The P2Y2 Nucleotide Receptor in Vascular Inflammation and Angiogenesis -- Role of Purine-Converting Ecto-Enzymes in Angiogenic Phenotype of Pulmonary Artery Adventitial Vasa Vasorum Endothelial Cells of Chronically Hypoxic Calves -- Stimulation of Wound Revascularization by Adenosine Receptor Activation -- Hypoxia-Inducible Factors and Adenosine Signaling in Vascular Growth -- Regulated Extracellular Nucleotide Metabolism and Function at the Mucosa -- Cell Surface ATP Synthase: A Potential Target for Anti-Angiogenic Therapy -- ATP Release Via Connexin Hemichannels Controls Intercellular Propagation of Ca2+ Waves in Corneal Endothelial Cells -- Pregnancy Induced Reprogramming of Endothelial Function in Response to ATP: Evidence for Post Receptor Ca2+ Signaling Plasticity -- Purinergic Signalling in Pancreatic Islet Endothelial Cells.
520 _aExtracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes. In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented. In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.
650 0 _aMedicine.
650 0 _aBiochemistry.
650 0 _aPathology.
650 0 _aCytokines.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aMedical Biochemistry.
650 2 4 _aCytokines and Growth Factors.
650 2 4 _aCell Physiology.
650 2 4 _aPathology.
650 2 4 _aBiomedicine general.
700 1 _aKaczmarek, Elzbieta.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048134342
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-3435-9
912 _aZDB-2-SBL
999 _c113349
_d113349