000 04891nam a22004815i 4500
001 978-90-481-3271-3
003 DE-He213
005 20140220084557.0
007 cr nn 008mamaa
008 100316s2010 ne | s |||| 0|eng d
020 _a9789048132713
_9978-90-481-3271-3
024 7 _a10.1007/978-90-481-3271-3
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aIslam, Md. Shahidul.
_eeditor.
245 1 4 _aThe Islets of Langerhans
_h[electronic resource] /
_cedited by Md. Shahidul Islam.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2010.
300 _aXXII, 800p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v654
505 0 _aMicroscopic Anatomy of the Human Islet of Langerhans -- The Comparative Anatomy of Islets -- Approaches for Imaging Islets: Recent Advances and Future Prospects -- Islet Cell Development -- High Fat Programming of ?-Cell Failure -- Nutrient Regulation of Insulin Secretion and ?-Cell Functional Integrity -- Electrophysiology of Islet Cells -- ATP-Sensitive Potassium Channels in Health and Disease -- Role of Mitochondria in ?-cell Function and Dysfunction -- Basement Membrane in Pancreatic Islet Function -- Calcium Signaling in the Islets -- Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets -- Cyclic AMP Signaling in Pancreatic Islets -- Exocytosis in Islet ?-Cells -- The Novel Roles of Glucagon-Like Peptide-1, Angiotensin II, and Vitamin D in Islet Function -- Proteomics and Islet Research -- Wnt Signaling in Pancreatic Islets -- Molecular Pathways Underlying the Pathogenesis of Pancreatic ?-Cell Dysfunction -- Mechanisms of Pancreatic ?-Cell Apoptosis in Diabetes and Its Therapies -- ?-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice] -- Islet Structure and Function in the GK Rat -- The ?-Cell in Human Type 2 Diabetes -- Clinical Approaches to Preserve ?-Cell Function in Diabetes -- Immunology of ?-Cell Destruction -- Toll-Like Receptors and Type 1 Diabetes -- Prevention of ?-Cell Destruction in Autoimmune Diabetes: Current Approaches and Future Prospects -- In Vivo Regeneration of Insulin-Producing ?-Cells -- Customized Cell-Based Treatment Options to Combat Autoimmunity and Restore ?-Cell Function in Type 1 Diabetes Mellitus: Current Protocols and Future Perspectives -- The Programmable Cell of Monocytic Origin (PCMO): A Potential Adult Stem/Progenitor Cell Source for the Generation of Islet Cells -- Islet Isolation for Clinical Transplantation -- Human Islet Autotransplantation: The Trail Thus Far and the Highway Ahead -- Modulation of Early Inflammatory Reactions to Promote Engraftment and Function of Transplanted Pancreatic Islets in Autoimmune Diabetes -- Successes and Disappointments with Clinical Islet Transplantation -- Islet Cell Tumours.
520 _aThis book is a unique and thoughtful blend of critical background information and advances made in a multitude of areas of contemporary islet research. It is an essential reference book, the first of its kind in many years, for professionals as well as for the beginners interested in the study of islet physiology and diabetes. The book is unique in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, islet transplantation, and finally islet tumors. Individual chapters contributed by over a hundred experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. It is a valuable compilation that one would love to possess personally and buy as a present to a colleague.
650 0 _aMedicine.
650 0 _aDiabetes.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aDiabetes.
650 2 4 _aCell Biology.
650 2 4 _aCell Physiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048132706
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v654
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-3271-3
912 _aZDB-2-SBL
999 _c113306
_d113306