000 04271nam a22004815i 4500
001 978-90-481-3144-0
003 DE-He213
005 20140220084557.0
007 cr nn 008mamaa
008 100301s2010 ne | s |||| 0|eng d
020 _a9789048131440
_9978-90-481-3144-0
024 7 _a10.1007/978-90-481-3144-0
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aBorea, Pier Andrea.
_eeditor.
245 1 0 _aA3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics
_h[electronic resource] /
_cedited by Pier Andrea Borea.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2010.
300 _bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aFrom Hypertension (+) to Asthma: Interactions with the Adenosine A3 Receptor from a Personal Perspective -- Physico-chemical Properties and Molecular Biology -- Thermodynamic Analysis in Drug–Receptor Binding: The A3 Adenosine Receptor -- Pharmacology and Molecular Biology of A3 Adenosine Receptors -- Signal Transduction -- Regulation of Second Messenger Systems and Intracellular Pathways -- The Desensitisation as A3 Adenosine Receptor Regulation: Physiopathological Implications -- Medicinal Chemistry -- A3 Adenosine Receptor Agonists: History and Future Perspectives -- A3 Adenosine Receptor Antagonists: History and Future Perspectives -- Molecular Modeling and Reengineering of A3 Adenosine Receptors -- Effects on Tissues and Organs and Therapeutic Applications -- Adenosine A3 Receptor Signaling in the Central Nervous System -- Cardiovascular Biology of the A3 Adenosine Receptor -- A3 Adenosine Receptor in the Pulmonary System -- A3 Adenosine Receptor Regulation of Cells of the Immune System and Modulation of Inflammation -- Adenosine A3 Receptors in Muscle Protection -- A3 Adenosine Receptors, HIF-1 Modulation and Atherosclerosis -- Inflammatory and Auto-Immune Diseases -- Rheumatoid Arthritis: History, Molecular Mechanisms and Therapeutic Applications -- Cancer -- Agonists and Antagonists: Molecular Mechanisms and Therapeutic Applications.
520 _aThis Book "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics " documents the present state of knowledge of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that function in physiology and intracellular signaling and are involved in inflammatory responses and mediating cell proliferation and cell death. The A3 receptor is increasingly being recognized for its biological roles throughout the body, and many A3 receptor ligands have proven useful in elucidating peripheral and central pathologies. This book covers a wide range of information including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. The book includes sections on: A3 Adenosine Receptor signal transduction Adenosine Receptor medicinal chemistry Effects and therapeutic applications of Adenosine Receptors on tissues and organs Adenosine Receptors and inflammatory and auto-immune diseases Adenosine Receptors and cancer The chapters in this book cover both fundamental science and relevant applications and provide an authoritative account of the current status of the field. "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics" is an up to date and scientifically excellent source of information, attractive to basic and clinical scientists alike.
650 0 _aMedicine.
650 0 _aToxicology.
650 0 _aBiochemistry.
650 0 _aCardiology.
650 0 _aPneumology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aMedicinal Chemistry.
650 2 4 _aCardiology.
650 2 4 _aPneumology/Respiratory System.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048131433
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-3144-0
912 _aZDB-2-SBL
999 _c113276
_d113276