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001 978-90-481-2582-1
003 DE-He213
005 20140220084555.0
007 cr nn 008mamaa
008 100825s2010 ne | s |||| 0|eng d
020 _a9789048125821
_9978-90-481-2582-1
024 7 _a10.1007/978-90-481-2582-1
_2doi
050 4 _aRS400-431
072 7 _aPSB
_2bicssc
072 7 _aSCI013020
_2bisacsh
082 0 4 _a615.19
_223
100 1 _aCragg, Peter J.
_eauthor.
245 1 0 _aSupramolecular Chemistry
_h[electronic resource] :
_bFrom Biological Inspiration to Biomedical Applications /
_cby Peter J. Cragg.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2010.
300 _aXV, 260p. 140 illus., 50 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aAn Introduction to Supramolecular Chemistry -- Supramolecular Chemistry and the Life Sciences -- Artificial Cells -- Supramolecular Enzyme Mimics -- Natural and Synthetic Transmembrane Channels -- Diagnostic Applications -- Supramolecular Therapeutics -- Bionanotechnology, Nanomedicine and the Future.
520 _aSupramolecular chemistry is often described as the study of chemistry beyond the simple molecular level yet it is often forgotten how many of the pioneering su-pramolecular chemists looked to molecular biology for their ideas. The search for an aldolase enzyme mimic, the discovery of crown ethers that transported potas-sium as efficiently as valinomycin, and the synthesis of an antitubercular com-pound that resembled a transmembrane protein, all point to a biological inspira-tion. Since the field emerged in the last quarter of the 20th Century, advances in the synthesis of multifunctional molecules, coupled to a greater understanding of biological processes at the molecular level, have led supramolecular chemists to design compounds that not only mimic those in Nature but also have diagnostic and therapeutic applications. The book opens with an overview of supramolecular chemistry. In subsequent chapters parallels are drawn with biological phenomena: the formation of proteins and other biomolecules, the evolution of cells, and the design of channel-forming molecules and enzymes. The application of supramolecular principles to sensors and magic bullet therapies is explained and the future of supramolecular therapeutics is considered. The exciting combination of supramolecular chemistry and nanotechnology is discussed together with the likelihood that nanoengineered smart materials could one day circulate in the body to treat patients before they became aware of any symptoms. Supramolecular Chemistry: From Biological Inspiration to Biomedical Applications is aimed at postgraduates working at the chemistry/life science interface and final year undergraduate advanced options in supramolecular chemistry. It is hoped that it will also be of value to academics and professionals interested in the relevance of supramolecular chemistry to biology and vice versa.
650 0 _aChemistry.
650 0 _aMedicine.
650 0 _aChemistry, Organic.
650 0 _aBiochemistry.
650 0 _aPharmacy.
650 1 4 _aChemistry.
650 2 4 _aMedicinal Chemistry.
650 2 4 _aMolecular Medicine.
650 2 4 _aPharmacy.
650 2 4 _aOrganic Chemistry.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048125814
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-2582-1
912 _aZDB-2-CMS
999 _c113204
_d113204