000 03198nam a22004815i 4500
001 978-3-642-13329-9
003 DE-He213
005 20140220084537.0
007 cr nn 008mamaa
008 100929s2010 gw | s |||| 0|eng d
020 _a9783642133299
_9978-3-642-13329-9
024 7 _a10.1007/978-3-642-13329-9
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aSimon, M. Celeste.
_eeditor.
245 1 0 _aDiverse Effects of Hypoxia on Tumor Progression
_h[electronic resource] /
_cedited by M. Celeste Simon.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2010.
300 _aX, 146 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v345
505 0 _aThe HIF-2?-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization -- Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance -- Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression -- The Role of Hypoxia Regulated microRNAs in Cancer -- Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration -- Hypoxia-Inducible Factors as Essential Regulators of Inflammation -- Hypoxia and Metastasis in Breast Cancer.
520 _aSolid tumors frequently contain areas of oxygen deprivation (hypoxia) due to rapid cell proliferation and/or vascular insufficiency. The presence of hypoxic domains typically correlates with poor patient prognosis, due to the relative resistance of hypoxic cells to conventional cancer therapies and effects of O2 availability on disease progression. The response of malignant cells to hypoxia has been the focus of intense research over the last decade. In this issue of Current Topics in Microbiology and Immunology, the authors present articles describing the impact of hypoxia on components of the tumor microenvironment (such as endothelial cells, inflammatory cells, and tumor associated fibroblasts), the expression of unique microRNAs, tumor cell differentiation status, and metastasis. Each review article describes the state of the field studying these topics, and poses important questions for the future. The overall goal is to depict tumor phenotypes and associated molecular pathways to be exploited in the development of novel therapeutics to be used against a broad spectrum of human cancers.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aHuman physiology.
650 0 _aEmbryology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aEmbryology.
650 2 4 _aHuman Physiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642133282
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v345
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-13329-9
912 _aZDB-2-SBL
999 _c112234
_d112234