000 03154nam a22004695i 4500
001 978-3-642-12639-0
003 DE-He213
005 20140220084535.0
007 cr nn 008mamaa
008 101013s2010 gw | s |||| 0|eng d
020 _a9783642126390
_9978-3-642-12639-0
024 7 _a10.1007/978-3-642-12639-0
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aBruserud, Oystein.
_eeditor.
245 1 4 _aThe Chemokine System in Experimental and Clinical Hematology
_h[electronic resource] /
_cedited by Oystein Bruserud.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2010.
300 _aXII, 208 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v341
505 0 _aThe Chemokine System in Experimental and Clinical Hematology -- Chemokine Decoy Receptors: Structure–Function and Biological Properties -- Role of Chemokines in the Biology of Natural Killer Cells -- Chemokines in Angiogenesis -- Genetic Polymorphisms in the Cytokine and Chemokine System: Their Possible Importance in Allogeneic Stem Cell Transplantation -- The Chemokine System: A Possible Therapeutic Target in Acute Graft Versus Host Disease -- Homing in on Acute Graft vs. Host Disease: Tissue-Specific T Regulatory and Th17 Cells -- The Chemokine Network in Acute Myelogenous Leukemia: Molecular Mechanisms Involved in Leukemogenesis and Therapeutic Implications -- CXCR4 in Clinical Hematology -- Immunobiology of Heparin-Induced Thrombocytopenia.
520 _aThe aim of the issue is to describe and explain the importance of the chemokine system in hematology. As described in the introduction the chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation.” The present reviews illustrate that chemokines can be involved in leukemogenesis. The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as for immunoregulation in patients treated with allogeneic stem cell transplantation. Thus, chemokines are important both for the pathogenesis and treatment of hematological diseases.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aHematology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aHematology.
650 2 4 _aCancer Research.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642126383
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v341
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-12639-0
912 _aZDB-2-SBL
999 _c112116
_d112116