000 04480nam a22004935i 4500
001 978-3-642-04300-0
003 DE-He213
005 20140220084526.0
007 cr nn 008mamaa
008 100316s2010 gw | s |||| 0|eng d
020 _a9783642043000
_9978-3-642-04300-0
024 7 _a10.1007/978-3-642-04300-0
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aCraft, Suzanne.
_eeditor.
245 1 0 _aDiabetes, Insulin and Alzheimer's Disease
_h[electronic resource] /
_cedited by Suzanne Craft, Yves Christen.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2010.
300 _aXIII, 250p. 30 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aResearch and Perspectives in Alzheimer's Disease,
_x0945-6066
505 0 _aInsulin Action in the Brain and the Pathogenesis of Alzheimer’s Disease -- The Brain-insulin Connection, Metabolic Diseases and Related Pathologies -- Insulin-Mediated Neuroplasticity in the Central Nervous System -- Stress Hormones and Neuroplasticity in the Diabetic Brain -- Diabetes and the Brain – An Epidemiologic Perspective -- Cognition in Type 2 Diabetes: Brain Imaging Correlates and Vascular and Metabolic Risk Factors -- The Relationship Between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late-onset Alzheimer’s Disease: An Epidemiological Perspective -- The Role of Insulin Dysregulation in Aging and Alzheimer’s Disease -- Is Alzheimer’s a Disorder of Ageing and Why Don’t Mice get it? The Centrality of Insulin Signalling to Alzheimer’s Disease Pathology -- PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD -- Diet, Abeta Oligomers and Defective Insulin and Neurotrophic Factor Signaling in Alzheimer’s Disease -- Serum IGF-I, Life Style, and Risk of Alzheimer’s disease.
520 _aNeurons share more similarities with insulin-producing pancreatic islet cells than with any other cell type. The root of this similarity may lie in the islet’s evolution from an ancestral insulin-producing neuron. The islet-neuron connection becomes less surprising as we learn more about insulin’s involvement in functions far from its traditional role in mediating glucose uptake in muscle. The importance of insulin in the regulation of corporal aging has been established by the dramatic increases in longevity experienced by animals in which the adipose insulin receptor has been genetically eliminated, or in which the insulin-related daf genes have been mutated. New research suggests that, analogous to its influence on corporal aging, insulin also makes important contributions to brain aging and the expression of late-life neurodegenerative disease. Insulin plays a key role in cognition and other aspects of normal brain function. Insulin resistance induces chronic peripheral insulin elevations and is associated with reduced insulin activity both in periphery and brain. The insulin resistance syndrome underlies conditions such as Type 2 diabetes mellitus and hypertension, which are associated with age-related cognitive impairment and Alzheimer’s disease. This book discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease. Given the recent pandemic of conditions associated with insulin resistance, it is imperative that we achieve a comprehensive knowledge of the mechanisms through which insulin resistance affects brain function in order to develop therapeutic strategies to address these effects.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aGeriatrics.
650 0 _aEndocrinology.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aEndocrinology.
650 2 4 _aGeriatrics/Gerontology.
700 1 _aChristen, Yves.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642042997
830 0 _aResearch and Perspectives in Alzheimer's Disease,
_x0945-6066
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-04300-0
912 _aZDB-2-SBL
999 _c111588
_d111588