000 03453nam a22005175i 4500
001 978-3-642-03103-8
003 DE-He213
005 20140220084524.0
007 cr nn 008mamaa
008 100301s2010 gw | s |||| 0|eng d
020 _a9783642031038
_9978-3-642-03103-8
024 7 _a10.1007/978-3-642-03103-8
_2doi
050 4 _aQH345
050 4 _aQD415-436
072 7 _aPSB
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572
_223
100 1 _aRhoads, Robert E.
_eeditor.
245 1 0 _amiRNA Regulation of the Translational Machinery
_h[electronic resource] /
_cedited by Robert E. Rhoads.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2010.
300 _aX, 115p. 23 illus., 4 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProgress in Molecular and Subcellular Biology,
_x0079-6484 ;
_v50
505 0 _aUnderstanding How miRNAs Post-Transcriptionally Regulate Gene Expression -- Translational Control of Endogenous MicroRNA Target Genes in -- Translational Inhibition by MicroRNAs in Plants -- Regulation of p27 mRNA Expression by MicroRNAs -- The Inhibitory Effect of Apolipoprotein B mRNA-Editing Enzyme Catalytic Polypeptide-Like 3G (APOBEC3G) and Its Family Members on the Activity of Cellular MicroRNAs -- MicroRNA-Mediated mRNA Deadenylation and Repression of Protein Synthesis in a Mammalian Cell-Free System -- miRNA Effects on mRNA Closed-Loop Formation During Translation Initiation.
520 _aThe silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1).
650 0 _aLife sciences.
650 0 _aGene expression.
650 0 _aMedicine.
650 0 _aBiochemistry.
650 0 _aCytology.
650 1 4 _aLife Sciences.
650 2 4 _aBiochemistry, general.
650 2 4 _aCell Biology.
650 2 4 _aGene Expression.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642031021
830 0 _aProgress in Molecular and Subcellular Biology,
_x0079-6484 ;
_v50
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-03103-8
912 _aZDB-2-SBL
999 _c111467
_d111467