000 03396nam a22005415i 4500
001 978-3-642-02155-8
003 DE-He213
005 20140220084523.0
007 cr nn 008mamaa
008 100301s2010 gw | s |||| 0|eng d
020 _a9783642021558
_9978-3-642-02155-8
024 7 _a10.1007/978-3-642-02155-8
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aKlein, Sabra L.
_eeditor.
245 1 0 _aSex Hormones and Immunity to Infection
_h[electronic resource] /
_cedited by Sabra L. Klein, Craig Roberts.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2010.
300 _aX, 319p. 2 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aSex Differences in Susceptibility to Infection: An Evolutionary Perspective -- Effects of Sex Steroids on Innate and Adaptive Immunity -- Sex Steroid Receptors in Immune Cells -- Sex Differences in Susceptibility to Viral Infection -- Sex Differences in Innate Immune Responses to Bacterial Pathogens -- Sex Hormones and Regulation of Host Responses Against Parasites -- Sex Differences in Parasitic Infections: Beyond the Dogma of Female-Biased Resistance -- Progesterone, Pregnancy, and Innate Immunity -- Pregnancy and Susceptibility to Parasites -- Sex Steroids and Risk of Female Genital Tract Infection -- Sex, Pregnancy and Measles -- Epilogue: Challenges for the Future.
520 _aWhy sex matters Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases. The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes. The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology. The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aEndocrinology.
650 0 _aBiochemistry.
650 0 _aEvolution (Biology).
650 0 _aMicrobiology.
650 0 _aAnimal genetics.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aEvolutionary Biology.
650 2 4 _aEndocrinology.
650 2 4 _aAnimal Biochemistry.
650 2 4 _aAnimal Genetics and Genomics.
650 2 4 _aMicrobiology.
700 1 _aRoberts, Craig.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642021541
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-02155-8
912 _aZDB-2-SBL
999 _c111392
_d111392