000			03248nam a22005295i 4500
001			978-3-0346-0165-8
003			DE-He213
005			20140220084517.0
007			cr nn 008mamaa
008			110128s2010 sz | s |||| 0|eng d
020			_a9783034601658 _9978-3-0346-0165-8
024	7		_a10.1007/978-3-0346-0165-8 _2doi
050		4	_aRB155.8
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a615.895 _223
100	1		_aChernajovsky, Yuti. _eeditor.
245	1	0	_aGene Therapy for Autoimmune and Inflammatory Diseases _h[electronic resource] / _cedited by Yuti Chernajovsky, Paul D. Robbins.
264		1	_aBasel : _bSpringer Basel, _c2010.
300			_aXI, 239 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMilestones in Drug Therapy
505	0		_aGene therapy for arthritis -- Gene therapy for the treatment of inflammatory bowel disease -- Gene therapy for diabetes -- Gene therapy for cystic fibrosis lung disease -- Gene therapy of multiple sclerosis -- Gene therapy for myositis -- Gene therapy for osteoarthritis -- Gene therapy: Sjögren’s syndrome -- Disease mechanisms, genetic susceptibility and therapeutic approaches in lupus disease -- Regulated promoters -- Development of AAV vectors for the therapy of autoimmune and inflammatory diseases -- Delivery and application of plasmid DNA in arthritis gene therapy -- Helper-dependent adenoviral vectors -- Cells as carriers of gene therapy -- Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapy.
520			_aThis book addresses the latest advances in viral and non-viral vectors, novel targets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. The first section of the book deals with current research approaches for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery and vector development including plasmids, regulated promoters, adenovirus gutted vectors and adeno-associated vectors. All chapters are summarised by leaders in these fields. A must read for post graduate students, clinical and non-clinical researchers in the disciplines of immunology, molecular medicine, pharmacology, gene and cell-mediated therapy.
650		0	_aMedicine.
650		0	_aGene therapy.
650		0	_aImmunology.
650		0	_aToxicology.
650		0	_aRheumatology.
650	1	4	_aBiomedicine.
650	2	4	_aGene Therapy.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aImmunology.
650	2	4	_aRheumatology.
650	2	4	_aMolecular Medicine.
700	1		_aRobbins, Paul D. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783034601641
830		0	_aMilestones in Drug Therapy
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-0346-0165-8
912			_aZDB-2-SBL
999			_c111088 _d111088