| 000 | 04572nam a22005415i 4500 | ||
|---|---|---|---|
| 001 | 978-1-60761-280-3 | ||
| 003 | DE-He213 | ||
| 005 | 20140220084512.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 100301s2010 xxu| s |||| 0|eng d | ||
| 020 |
_a9781607612803 _9978-1-60761-280-3 |
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| 024 | 7 |
_a10.1007/978-1-60761-280-3 _2doi |
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| 050 | 4 | _aRC321-580 | |
| 072 | 7 |
_aPSAN _2bicssc |
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| 072 | 7 |
_aMED057000 _2bisacsh |
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| 082 | 0 | 4 |
_a612.8 _223 |
| 100 | 1 |
_aAnnunziato, Lucio. _eeditor. |
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| 245 | 1 | 0 |
_aNew Strategies in Stroke Intervention _h[electronic resource] : _bIonic Transporters, Pumps, and New Channels / _cedited by Lucio Annunziato. |
| 264 | 1 |
_aTotowa, NJ : _bHumana Press, _c2010. |
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| 300 |
_aXV, 254p. 12 illus., 6 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 | _aContemporary Neuroscience | |
| 505 | 0 | _aBasis of Ionic Dysregulation in Cerebral Ischemia -- Why have Ionotropic and Metabotropic Glutamate Antagonists Failed in Stroke Therapy? -- Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia -- Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke -- The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia -- The “Loop” Diuretic Drug Bumetanide-Sensitive Na + -K + -Cl - Cotransporter in Cerebral Ischemia -- The Na + /H + Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia -- The Na + /K + -ATPase as a Drug Target for Ischemic Stroke -- Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment -- Role of TRPM7 in Ischemic CNS Injury -- Subtypes of Voltage-Gated Ca 2+ Channels and Ischemic Brain Injury -- The Diverse Roles of K + Channels in Brain Ischemia -- Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke. | |
| 520 | _aIschemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized to treat stroke and promising avenues have not proven clinically useful. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure. It will be a useful tool for researchers working in this field, and any student interested in the physiological, pathophysiological, and pharmacological features of stroke damage. About the Editor: Lucio Annunziato is a professor of pharmacology in the School of Medicine at the University of Naples ‘‘Federico II’’, Italy. He is coordinator of the University's neuroscience Ph.D. program and director of the Department of Neuroscience. He is also the president elect of the Italian Society of Neuroscience. Dr. Annunziato has authored more than 150 full papers and his scientific interest is mainly devoted to the molecular pharmacology of plasma membrane transporters and ionic channels involved in the pathophysiology of stroke. Most of his recent papers have appeared in the most qualified international journals in the field of ischemic neurodegeneration. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aNeurosciences. | |
| 650 | 0 | _aToxicology. | |
| 650 | 0 | _aAnesthesiology. | |
| 650 | 0 | _aCardiology. | |
| 650 | 0 | _aNeurology. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aNeurosciences. |
| 650 | 2 | 4 | _aNeurology. |
| 650 | 2 | 4 | _aCardiology. |
| 650 | 2 | 4 | _aMolecular Medicine. |
| 650 | 2 | 4 | _aPharmacology/Toxicology. |
| 650 | 2 | 4 | _aAnesthesiology. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781607612797 |
| 830 | 0 | _aContemporary Neuroscience | |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-60761-280-3 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c110810 _d110810 |
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