000			02904nam a22004575i 4500
001			978-1-60327-013-7
003			DE-He213
005			20140220084512.0
007			cr nn 008mamaa
008			100301s2010 xxu| s |||| 0|eng d
020			_a9781603270137 _9978-1-60327-013-7
024	7		_a10.1007/978-1-60327-013-7 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
100	1		_aCancro, Michael P. _eeditor.
245	1	0	_aBLyS Ligands and Receptors _h[electronic resource] / _cedited by Michael P. Cancro.
264		1	_aTotowa, NJ : _bHumana Press, _c2010.
300			_aXI, 284p. 40 illus., 21 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aContemporary Immunology
505	0		_aThe Beautiful Structures of BAFF, APRIL, and Their Receptors -- BAFF Receptor Regulation of Peripheral B-Lymphocyte Survival and Development -- Regulation of B-Cell Self-Tolerance By BAFF and the Molecular Basis of Its Action -- Role of BAFF and APRIL in Antibody Production and Diversification -- Signal Transduction by Receptors for BAFF and APRIL -- TACI Signaling and Its Role in Immunity -- The BAFF/APRIL System in Autoimmunity -- Systemic Immune-Based Rheumatic Diseases: Blissless States of BLySfulness -- The Role of BAFF and APRIL in Regulating Human B-Cell Behaviour: Implications for Disease Pathogenesis -- Translation of BAFF Inhibition from Mouse to Non-human Primate and Human -- BLyS/BR3 Receptor Signaling in the Biology and Pathophysiology of Aggressive B-Cell Lymphomas -- Tipping the Scales of Survival: The Role of BLyS in B-Cell Malignancies.
520			_aThe BLyS/BAFF family of cytokines and receptors has captured and held the attention of B cell biologists during the last decade. Discovery of the two ligands and three receptors comprising this family has yielded a watershed of insights; fostering fresh paradigms in our views about the differentiation, selection, and homeostatic control of virtually all B cell subsets. Moreover, because these processes are intimately tied to the mechanistic underpinnings of immune tolerance and activation, increased understanding of these activities promises translational progress in autoimmunity, neoplasia, and transplantation.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aMicrobiology.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aMicrobiology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781603270120
830		0	_aContemporary Immunology
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-60327-013-7
912			_aZDB-2-SBL
999			_c110773 _d110773