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001 978-1-4419-6676-6
003 DE-He213
005 20140220084510.0
007 cr nn 008mamaa
008 110110s2010 xxu| s |||| 0|eng d
020 _a9781441966766
_9978-1-4419-6676-6
024 7 _a10.1007/978-1-4419-6676-6
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aGroettrup, Marcus.
_eeditor.
245 1 0 _aConjugation and Deconjugation of Ubiquitin Family Modifiers
_h[electronic resource] :
_bSubcellular Biochemistry /
_cedited by Marcus Groettrup.
264 1 _aNew York, NY :
_bSpringer New York,
_c2010.
300 _aXX, 252p. 58 illus., 16 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v54
505 0 _aActivation of Ubiquitin and Ubiquitin-Like Proteins -- Control of Ubiquitin Conjugation by Cdc48 and Its Cofactors -- Regulation of Ubiquitin Receptors by Coupled Monoubiquitination -- Control of Cullin-Ring Ubiquitin Ligase Activity by Nedd8 -- Control of Deneddylation by the COP9 Signalosome -- Mechanism, Specificity and Structure of the Deubiquitinases -- Ubiquitin Conjugation and Deconjugation in NF-?B Signaling -- Functions of Linear Ubiquitin Chains in the NF-?B Pathway -- Assembly of K11-Linked Ubiquitin Chains by the Anaphase-Promoting Complex -- Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53 -- Ubiquitylation in the ERAD Pathway -- Pupylation -- Sumo Control -- The In Vivo Functions of Desumoylating Enzymes -- Regulatory Functions of Ubiquitin and SUMO in DNA Repair Pathways -- Sumoylation as a Signal for Polyubiquitylation and Proteasomal Degradation -- In Vivo Functions of Isgylation -- Identification and Validation of ISG15 Target Proteins -- FAT10.
520 _aTo cope with the steadily growing body of knowledge and for organizational reasons the articles in this book are focussed on the modifiers ubiquitin, SUMO1/2/3, NED 8, ISG15 and FAT10 but it should be at least mentioned here that enzymes involved in conjugation and deconjugation of URM1, UFM1, ATG8 and ATG12 have been reported and continue to be investigated.
650 0 _aMedicine.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441966759
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v54
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-6676-6
912 _aZDB-2-SBL
999 _c110677
_d110677