000 03663nam a22004335i 4500
001 978-1-4419-1664-8
003 DE-He213
005 20140220084506.0
007 cr nn 008mamaa
008 100728s2010 xxu| s |||| 0|eng d
020 _a9781441916648
_9978-1-4419-1664-8
024 7 _a10.1007/978-1-4419-1664-8
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aBalogh, Katalin.
_eeditor.
245 1 0 _aSuperMEN1
_h[electronic resource] :
_bPituitary, Parathyroid and Pancreas /
_cedited by Katalin Balogh, Attila Patocs.
264 1 _aNew York, NY :
_bSpringer New York,
_c2010.
300 _bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v668
505 0 _aMEN1 Clinical Background -- Genetic Background of MEN1: From Genetic Homogeneity to Functional Diversity -- Menin: The Protein Behind the MEN1 Syndrome -- Cellular Functions of Menin -- The Role of Menin in Hematopoiesis -- Role of Menin in Bone Development -- Activin, TGF-? and Menin in Pituitary Tumorigenesis -- The Role of Menin in Parathyroid Tumorigenesis -- Role of Menin in Neuroendocrine Tumorigenesis -- Adrenal Tumors in MEN1 Syndrome and the Role of Menin in Adrenal Tumorigenesis -- Functional Studies of Menin through Genetic Manipulation of the Men1 Homolog in Mice.
520 _aThe vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. SuperMEN1, Pituitary, Parathyroid and Pancreas provides an up-to-date summary from clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type 1 syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgrounds of this syndrome and to review carefully the latest discoveries concerning the possible functions and interactions of menin, the protein encoded by the MEN1 gene, including its possible role in cell cycle regulation, hematopoiesis, and bone development. The goal of this valume is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN 1 syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presenting a comprehensive and current overview of basic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type 1.
650 0 _aMedicine.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
700 1 _aPatocs, Attila.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441916624
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v668
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-1664-8
912 _aZDB-2-SBL
999 _c110445
_d110445