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020 _a9781441912435
_9978-1-4419-1243-5
024 7 _a10.1007/978-1-4419-1243-5
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aPallas, Sarah L.
_eeditor.
245 1 0 _aDevelopmental Plasticity of Inhibitory Circuitry
_h[electronic resource] /
_cedited by Sarah L. Pallas.
264 1 _aBoston, MA :
_bSpringer US,
_c2010.
300 _bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aThe Origins and Specification of Cortical Interneurons -- Role of Spontaneous Activity in the Maturation of GABAergic Synapses in Embryonic Spinal Circuits -- Regulation of Inhibitory Synapse Function in the Developing Auditory CNS -- Developmental Plasticity of Inhibitory Receptive Field Properties in the Auditory and Visual Systems -- Postnatal Maturation and Experience-Dependent Plasticity of Inhibitory Circuits in Barrel Cortex -- GABAergic Transmission and Neuronal Network Events During Hippocampal Development -- Endocannabinoids and Inhibitory Synaptic Plasticity in Hippocampus and Cerebellum -- Interneuron Pathophysiologies: Paths to Neurodevelopmental Disorders.
520 _aNeuroscience has long been focused on understanding neural plasticity in both development and adulthood. However, experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging. Only a few investigators have been engaged in research on how inhibitory circuits are formed during development or how they are involved in plasticity of developing sensory and motor circuitry. Developmental Plasticity of Inhibitory Circuitry approaches the subject of inhibitory plasticity from several levels of analysis, from synapses to circuits to systems to clinical, summarizing several possible mechanisms and collecting some of the most fascinating work in this under-studied area. It is meant to provide an overview for basic and clinical researchers and students interested in neural plasticity and to stimulate further research. About the Editor: Dr. Sarah L. Pallas is a Professor of Neuroscience and Biology at Georgia State University. She earned her Ph.D. in Neurobiology and Behavior at Cornell University, under the tutelage of Dr. Barbara Finlay. Her postdoctoral training was received at M.I.T. in the laboratory of Dr. Mriganka Sur. Her research concerns developmental neurobiology and sensory physiology, and in particular the role of sensory experience in the development and plasticity of neural circuits.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aNeurology.
650 0 _aRehabilitation.
650 0 _aDevelopmental biology.
650 0 _aNeurobiology.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aNeurobiology.
650 2 4 _aDevelopmental Biology.
650 2 4 _aNeurology.
650 2 4 _aRehabilitation Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441912428
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-1243-5
912 _aZDB-2-SBL
999 _c110353
_d110353