000			03758nam a22005055i 4500
001			978-1-4419-1207-7
003			DE-He213
005			20140220084504.0
007			cr nn 008mamaa
008			100301s2010 xxu| s |||| 0|eng d
020			_a9781441912077 _9978-1-4419-1207-7
024	7		_a10.1007/978-1-4419-1207-7 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
100	1		_aDuan, Dongsheng. _eeditor.
245	1	0	_aMuscle Gene Therapy _h[electronic resource] / _cedited by Dongsheng Duan.
264		1	_aNew York, NY : _bSpringer New York, _c2010.
300			_aXVI, 275p. 45 illus., 16 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aAnimal Models for Inherited Muscle Diseases -- In Utero Muscle Gene Transfer -- Gene Therapy for the Respiratory Muscles -- Muscular Dystrophy Gene Therapy in Small Animal Models -- Antisense-Mediated Exon Skipping for Duchenne Muscular Dystrophy -- Systemic Treatment of Duchenne Muscular Dystrophy by Antisense Oligomer-Induced Exon Skipping -- RNAi Therapy for Dominant Muscular Dystrophies and Other Myopathies -- Combinatorial Gene Therapy Strategies for Treating Muscular Dystrophies -- Duchenne Cardiomyopathy Gene Therapy -- Systemic Gene Delivery for Muscle Gene Therapy -- Modulating Immune Responses in Muscle Gene Therapy -- Delivering Large Therapeutic Genes for Muscle Gene Therapy -- Muscle as a Metabolic Factory for Gene Therapy -- Muscle as a Target for Genetic Vaccine -- Combining Stem Cells and Exon Skipping Strategy to Treat Muscular Dystrophy -- Gene Therapy Clinical Trials for Muscular Dystrophies.
520			_aMuscle disease represents an important health threat to the general population. For thousands of years, a cure has been deemed extremely remote, if not impossible, for many relentless muscle diseases such as Duchenne muscular dystrophy. The cloning of muscle disease genes and the prospect of introducing the normal gene to diseased muscle by gene therapy finally bring the hope of a cure. Tremendous progress has been made chasing the muscle gene therapy dream over the past two decades. Valuable information is scattered in the literature. This book represents the first compilation specifically dedicated to issues related to muscle gene therapy. It offers a much needed, up-to-date overview and perspective on the current strategies and status of muscle gene therapy. It covers the cutting edge development of a variety of fascinating strategies such as exon-skipping, AAV gene therapy, RNAi and stem cell approaches. With contributions from prominent investigators in the field, it provides a framework to translate bench science to clinical practice in the upcoming years. This book is a must-have for anyone who is interested in muscle gene therapy including established investigators, clinicians, post-doctoral fellows, graduate students, funding agencies, patients and their families and friends.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aImmunology.
650		0	_aMedical virology.
650		0	_aDevelopmental biology.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aDevelopmental Biology.
650	2	4	_aImmunology.
650	2	4	_aVirology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441912053
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-1207-7
912			_aZDB-2-SBL
999			_c110342 _d110342