000			03189nam a22004455i 4500
001			978-1-4419-1142-1
003			DE-He213
005			20140220084504.0
007			cr nn 008mamaa
008			100301s2010 xxu| s |||| 0|eng d
020			_a9781441911421 _9978-1-4419-1142-1
024	7		_a10.1007/978-1-4419-1142-1 _2doi
050		4	_aQD431-431.7
072		7	_aPSBC _2bicssc
072		7	_aSCI007000 _2bisacsh
082	0	4	_a572.6 _223
100	1		_aLiu, Fenyong. _eeditor.
245	1	0	_aRibonuclease P _h[electronic resource] / _cedited by Fenyong Liu, Sidney Altman.
264		1	_aNew York, NY : _bSpringer New York, _c2010.
300			_aXVI, 283p. 60 illus., 30 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProtein Reviews ; _v10
505	0		_aHistory of RNase P and Overview of Its Catalytic Activity -- The Evolution of RNase P and Its RNA -- Over a Decade of Bacterial Ribonuclease P Modeling -- Structural Studies of Ribonuclease P -- Folding of Bacterial RNase P RNA -- Kinetic Mechanism of Bacterial RNase P -- Roles of Metal Ions in RNase P Catalysis -- Challenges in RNase P Substrate Recognition: Considering the Biological Context -- Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives -- Eukaryote RNase P and RNase MRP -- RNase P from Organelles -- Human RNase P and Transcription -- RNase P as a Drug Target -- Ribonuclease P as a Tool.
520			_aRibonuclease P (RNaseP), a ribonucleoprotein, is an essential tRNA processing enzyme found in all living organisms. Since its discovery almost 40 years ago, research on RNase P has led to the discovery of the catalytic properties of RNA, and of the only known, naturally occurring RNA enzymes, RNase P catalytic RNA. The description of the catalytic properties of RNA has provided fundamental insight into the RNA world and these catalytic properties are being harnessed as therapeutic and prevention strategies for acquired and inherited diseases. Ribonuclease P is the first book to provide a comprehensive collection covering all aspects of current research on RNase P. The topics include kinetic and structural analysis, mechanism of catalysis, and its regulation and biogenesis in prokaryotes, eukaryotes, and organelles. Furthermore, research progresses on developing RNase P as a potential drug target for antimicrobial development and as a gene-targeting tool for anti-infective and anticancer therapy are also included. This book should be of general interests to molecular biologists and biochemists in both the academic section and pharmaceutical industry.
650		0	_aLife sciences.
650		0	_aProteomics.
650	1	4	_aLife Sciences.
650	2	4	_aProteomics.
700	1		_aAltman, Sidney. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441911414
830		0	_aProtein Reviews ; _v10
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-1142-1
912			_aZDB-2-SBL
999			_c110327 _d110327