000 02779nam a22004575i 4500
001 978-1-4419-1111-7
003 DE-He213
005 20140220084504.0
007 cr nn 008mamaa
008 100301s2010 xxu| s |||| 0|eng d
020 _a9781441911117
_9978-1-4419-1111-7
024 7 _a10.1007/978-1-4419-1111-7
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aGolen, Kenneth.
_eeditor.
245 1 4 _aThe Rho GTPases in Cancer
_h[electronic resource] /
_cedited by Kenneth Golen.
264 1 _aNew York, NY :
_bSpringer New York,
_c2010.
300 _aXXII, 206p. 25 illus., 13 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aAn Overview of the Rho GTPases -- Overview of Rho GTPase History -- Rho Proteins in Cancer -- The Rho Regulatory Proteins in Cancer -- RhoGDIs in Cancer -- Signaling through Galpha12/13 and RGS-RhoGEFs -- Vav Proteins in Cancer -- Rho GTPase-Activating Proteins in Cancer -- The Rho GTPase Proteins and Cancer -- RhoBTB Proteins in Cancer -- RhoC GTPase in Cancer Progression and Metastasis -- RhoB GTPase and FTIs in Cancer -- Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview -- The Rho-Regulated ROCK Kinases in Cancer.
520 _aThe Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aCell Biology.
650 2 4 _aPharmacology/Toxicology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441911100
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-1111-7
912 _aZDB-2-SBL
999 _c110320
_d110320