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001 978-1-4419-1075-2
003 DE-He213
005 20140220084504.0
007 cr nn 008mamaa
008 100301s2010 xxu| s |||| 0|eng d
020 _a9781441910752
_9978-1-4419-1075-2
024 7 _a10.1007/978-1-4419-1075-2
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aAdams, Peter D.
_eeditor.
245 1 0 _aCellular Senescence and Tumor Suppression
_h[electronic resource] /
_cedited by Peter D. Adams, John M. Sedivy.
264 1 _aNew York, NY :
_bSpringer New York,
_c2010.
300 _aXIII, 272p. 25 illus., 5 illus. in color. With 1 4-color insert.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aSenescence signals -- Telomere Biology and Biochemistry -- Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance -- Oncogene-Induced Senescence (OIS) as a Cellular Response to Oncogenic Stresses -- Stress-Induced Senescence -- The senescent phenotype -- The Secretome of Senescent Cells -- Chromatin Structure in Senescent Cells -- A Comparison of Senescence in Mouse and Human Cells -- The physiological consequences of senescence -- Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism -- Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging -- Mining Cellular Senescence for Drug Targets.
520 _aLeonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, showing that these cells can proliferate in vitro for about 55 population doublings before their proliferative capacity succumbs to irreversible proliferation arrest. Since those original observations, major advances in our understanding have come in several areas. We now know that several other triggers, in addition to proliferative exhaustion, can trigger the senescence program. One important class of senescence triggers, and a focus of this volume, are activated oncogenes in primary untransformed cells. There is now good evidence to indicate that senescence in response to this cue is a potent tumor suppressor mechanism, through its ability to block proliferation of incipient cancer cells. However, senescence is not simply a passive proliferation arrest that impacts only the senescent cell itself, but rather, senescent cells influence their environment and neighboring cells through an active secretory program. This secretory program appears to facilitate senescence as a tumor suppression process. Cellular Senescence and Tumor Suppression collects a number of chapters from leaders in the field to review the molecular basis of senescence and its physiological functions, with a particular emphasis on the role of senescence in tumor suppression.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aHuman genetics.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aHuman Genetics.
650 2 4 _aPharmacology/Toxicology.
700 1 _aSedivy, John M.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441910745
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-1075-2
912 _aZDB-2-SBL
999 _c110312
_d110312