000 04423nam a22004815i 4500
001 978-1-4419-0793-6
003 DE-He213
005 20140220084503.0
007 cr nn 008mamaa
008 130531s2010 xxu| s |||| 0|eng d
020 _a9781441907936
_9978-1-4419-0793-6
024 7 _a10.1007/978-1-4419-0793-6
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aMeucci, Olimpia.
_eeditor.
245 1 0 _aChemokine Receptors and NeuroAIDS
_h[electronic resource] :
_bBeyond Co-Receptor Function and Links to Other Neuropathologies /
_cedited by Olimpia Meucci.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2010.
300 _aXVI, 412p. 12 illus., 6 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aSection I -- HIV Neuroinvasion: Early Events, Late Manifestations -- HIV Co-receptors: The Brain Perspective -- HIV Infection and the PNS -- HIV Latency and Reactivation: Role in Neuropathogenesis -- HIV Coreceptors and Their Roles in Leukocyte Trafficking During Neuroinflammatory Diseases -- Section II -- Chemokine Proteolytic Processing in HIV Infection: Neurotoxic and Neuroimmune Consequences -- Chemokines and Chemokine Receptors in the Brain -- Chemokine Signaling in the Nervous System and Its Role in Development and Neuropathology -- Modulation of Neuronal Cell Cycle Proteins by Chemokine Receptors and Its Role in the Survival of Postmitotic Neurons -- Chemokines and Primary Brain Tumors -- Chemokines as Neuromodulators: Regulation of Glutamatergic Transmission by CXCR4-Mediated Glutamate Release From Astrocytes -- Role of CX3CL1 in Synaptic Activity and Neuroprotection -- Section III -- Interaction Between Opioid and Chemokine Receptors in Immune Cells: Implications for HIV Infection -- Chronic Morphine’s Role on Innate Immunity, Bacterial Susceptibility and Implications in Wound Healing -- Opioids, Astroglial Chemokines, Microglial Reactivity, and Neuronal Injury in HIV-1 Encephalitis -- Regulation of Neuronal Chemokine Receptor CXCR4 by ?-Opioid Agonists and Its Involvement in NeuroAIDS.
520 _aChemokines and their receptors are being recognized as an integral component of the nervous system implicated in fundamental aspects of development and homeostasis, such as neurotransmission, proliferation, differentiation, and neuronal-glial communication. Thus, their involvement in HIV neuropathology goes far beyond the co-receptors role and entails complex interactions of the chemokine system with different cell types and other regulators of neuronal function. The major goal of this volume is to review these topics in order to highlight alterations of chemokine physiology that may contribute to neuroAIDS and other neuropathologies. This book will be of interest to neuroscientists, neurologists, virologists, pharmacologists, and students in these fields. About the Editor: Olimpia Meucci, MD, PhD is a Professor of Pharmacology and Physiology & Microbiology and Immunology at Drexel University College of Medicine in Philadelphia, PA. Since her seminal discovery about the regulation of neuronal signaling by chemokines, her research has primarily focused on the physio-pathological roles of this important class of neuroimmune modulators in the central nervous system and their involvement in neuroAIDS. These studies have significantly contributed to current understanding of the cellular and molecular mechanisms of HIV-related neuropathology including the interaction of the chemokine system with drug of abuse, namely opiates, which continues to be a major area of investigation in the Meucci lab.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aToxicology.
650 0 _aMedical virology.
650 0 _aEmerging infectious diseases.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aVirology.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aInfectious Diseases.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441907929
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-0793-6
912 _aZDB-2-SBL
999 _c110254
_d110254