| 000 | 03534nam a22004215i 4500 | ||
|---|---|---|---|
| 001 | 978-94-007-1257-7 | ||
| 003 | DE-He213 | ||
| 005 | 20140220083832.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 110516s2011 ne | s |||| 0|eng d | ||
| 020 |
_a9789400712577 _9978-94-007-1257-7 |
||
| 024 | 7 |
_a10.1007/978-94-007-1257-7 _2doi |
|
| 050 | 4 | _aR-RZ | |
| 072 | 7 |
_aMBGR _2bicssc |
|
| 072 | 7 |
_aMED000000 _2bisacsh |
|
| 082 | 0 | 4 |
_a610 _223 |
| 100 | 1 |
_aAl-Rubeai, Mohamed. _eeditor. |
|
| 245 | 1 | 0 |
_aAntibody Expression and Production _h[electronic resource] / _cedited by Mohamed Al-Rubeai. |
| 264 | 1 |
_aDordrecht : _bSpringer Netherlands, _c2011. |
|
| 300 |
_aX, 346 p. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
||
| 337 |
_acomputer _bc _2rdamedia |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
||
| 347 |
_atext file _bPDF _2rda |
||
| 490 | 1 |
_aCell Engineering, _x1389-6946 ; _v7 |
|
| 505 | 0 | _a 1 Expression of antibody in mammalian cells, Thomas Jostock -- 2 Bioreactor systems for producing antibody from mammalian cells, Darrin Kuystermans and Mohamed Al-Rubeai -- 3 Production of antibody in insect cells, Hideki Yamaji -- 4 Production of monoclonal antibodies in glycoengineered Pichia pastoris, Dongxing Zhu, Thomas Linden and Thomas Potgieter -- 5 Production of antibodies in Hansenula polymorpha, Georg Melmer, Stephan Hellwig, Grit Hehmann and Ulrike Dahlems -- 6 Expression of antibody in transgenic avians, Yoshinori Kawabe and Masamichi Kamihira -- 7 Production of antibodies in plants, Alejandro Sarrion-Perdigones, Paloma Juarez, Antonio Granell and Diego Orzaez -- 8 Production of antibody fab fragments in Escherichia coli, Hiroshi Tachibana and Masataka Takekoshi -- 9 Intrabody expression in mammalian cells, Silvia Biocca -- 10 Engineering of antibodies for cancer therapy, Lisa E. Goldsmith and Matthew K. Robinson -- 11 Recombinant bispecific antibodies for cancer therapy, Dafne Muller and Roland Kontermann -- 12 The role of glycosylation in therapeutic antibodies, Maureen Spearman, Ben Dionne and Mike Butler -- 13 Quality issues arising from post-translational modification of recombinant antibodies, Raymond Tyther and Nigel Jenkins -- 14 Purification of antibody, XueJun Han, Arther Hewig and Ganesh Vedantham -- Index. | |
| 520 | _aEngineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aBiomedicine general. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9789400712560 |
| 830 | 0 |
_aCell Engineering, _x1389-6946 ; _v7 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-94-007-1257-7 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c109443 _d109443 |
||