000 03684nam a22005535i 4500
001 978-94-007-1217-1
003 DE-He213
005 20140220083832.0
007 cr nn 008mamaa
008 110510s2011 ne | s |||| 0|eng d
020 _a9789400712171
_9978-94-007-1217-1
024 7 _a10.1007/978-94-007-1217-1
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aPicher, Maryse.
_eeditor.
245 1 0 _aPurinergic Regulation of Respiratory Diseases
_h[electronic resource] /
_cedited by Maryse Picher, Richard C. Boucher.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2011.
300 _aXVIII, 282 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v55
505 0 _aDedication. Preface -- Chapter 1. Nucleotide Release by Airway Epithelia -- Chapter 2. Mechanisms Regulating Airway Nucleotides -- Chapter 3. Computational Model for the Regulation of Extracellular ATP and Adenosine in Airway Epithelia -- Chapter 4. Regulation of Airway Nucleotides in Chronic Lung Diseases -- Chapter 5. Nucleotide-Mediated Airway Clearance -- Chapter 6. Purinergic Signaling in Wound Healing and Airway Remodeling -- Chapter 7. Purinergic Regulation of Airway Inflammation -- Chapter 8. Animal Models of Airway Diseases -- Chapter 9. Therapeutic Applications. Index.
520 _aWe proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses. Then, chapters are devoted to the groundbreaking discovery that chronic respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), present specific aberrances in purinergic signaling which essentially drive lung complications. The last chapters describe the animal models used to investigate purinergic signaling in respiratory diseases, and the therapeutic applications developed by the pharmaceutical industry based on receptor agonists/antagonists and metabolic correctors. This highly comprehensive manuscript constitutes an invaluable tool for beginners and experts to follow the rapidly evolving research field of purinergic signaling. Furthermore, the critical analysis of past clinical protocols should facilitate the identification of potent therapeutic targets, and provide a better understanding of the data acquired in current clinical trials.
650 0 _aMedicine.
650 0 _aPharmaceutical technology.
650 0 _aEmerging infectious diseases.
650 0 _aMetabolic diseases.
650 0 _aPneumology.
650 0 _aTrauma.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aPneumology/Respiratory System.
650 2 4 _aPharmaceutical Sciences/Technology.
650 2 4 _aMetabolic Diseases.
650 2 4 _aInfectious Diseases.
650 2 4 _aTraumatic Surgery.
700 1 _aBoucher, Richard C.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400712164
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v55
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-1217-1
912 _aZDB-2-SBL
999 _c109432
_d109432