000			03115nam a22004695i 4500
001			978-90-481-9899-3
003			DE-He213
005			20140220083826.0
007			cr nn 008mamaa
008			101029s2011 ne | s |||| 0|eng d
020			_a9789048198993 _9978-90-481-9899-3
024	7		_a10.1007/978-90-481-9899-3 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aAdams, Niall M. _eeditor.
245	1	0	_aAdvances in Nuclear Architecture _h[electronic resource] / _cedited by Niall M. Adams, Paul S. Freemont.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2011.
300			_aVII, 210p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aForeword -- Nuclear subdomains and cancer, Kendra L. Cann, Sui Huang and Graham Dellaire -- Spatial point process analysis of Promyelocytic Leukemia nuclear bodies, Philip P. Umande and David A. Stephens -- Quantitative approaches to nuclear architecture analysis and modeling, D. Hübschmann, N. Kepper, C. Cremer and G. Kreth -- Statistical shape theory and registration methods for analyzing the 3D architecture of chromatin in interphase cell nuclei, Siwei Yang, Doris Illner, Kathrin Teller, Irina Solovei, Roel van Driel, Boris Joffe, Thomas Cremer, Roland Eils, Karl Rohr -- Nuclear molecular motors for active, directed chromatin movement in interphase nuclei, Joanna M. Bridger and Ishita S. Mehta -- Methodology for quantitative analysis of 3-D nuclear architecture, Richard A. Russell, Niall. M. Adams, David A. Stephens, Elizabeth Batty, Kirsten Jensen and Paul S. Freemont -- Thinking holistically about gene transcription, Dean A. Jackson -- Index.
520			_aThis book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.
650		0	_aMedicine.
650		0	_aMedical genetics.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aCell Biology.
650	2	4	_aGene Function.
650	2	4	_aCell Physiology.
700	1		_aFreemont, Paul S. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789048198986
856	4	0	_uhttp://dx.doi.org/10.1007/978-90-481-9899-3
912			_aZDB-2-SBL
999			_c109118 _d109118