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001 978-90-481-9437-7
003 DE-He213
005 20140220083824.0
007 cr nn 008mamaa
008 110201s2011 ne | s |||| 0|eng d
020 _a9789048194377
_9978-90-481-9437-7
024 7 _a10.1007/978-90-481-9437-7
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aCohen, G.N.
_eauthor.
245 1 0 _aMicrobial Biochemistry
_h[electronic resource] :
_bSecond Edition /
_cby G.N. Cohen.
250 _a2.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2011.
300 _aXXVIII, 500p. 141 illus., 6 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
520 _aMicrobial physiology, biochemistry, and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle. The level of readership presupposes some knowledge of chemistry and genetics at the undergraduate level. The target group is graduate students, researchers in academia and industry.
650 0 _aMedicine.
650 0 _aMicrobiology.
650 0 _aCell membranes.
650 0 _aMicrobial genetics.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aMicrobiology.
650 2 4 _aMembrane Biology.
650 2 4 _aMicrobial Genetics and Genomics.
650 2 4 _aMedical Microbiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048194360
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-9437-7
912 _aZDB-2-SBL
999 _c109028
_d109028