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001 978-3-7091-0733-1
003 DE-He213
005 20140220083818.0
007 cr nn 008mamaa
008 110711s2011 au | s |||| 0|eng d
020 _a9783709107331
_9978-3-7091-0733-1
024 7 _a10.1007/978-3-7091-0733-1
_2doi
050 4 _aQR1-502
072 7 _aPSG
_2bicssc
072 7 _aTCB
_2bicssc
072 7 _aSCI010000
_2bisacsh
072 7 _aSCI045000
_2bisacsh
082 0 4 _a660.62
_223
100 1 _aKnirel, Yuriy A.
_eeditor.
245 1 0 _aBacterial Lipopolysaccharides
_h[electronic resource] :
_bStructure, Chemical Synthesis, Biogenesis and Interaction with Host Cells /
_cedited by Yuriy A. Knirel, Miguel A. Valvano.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2011.
300 _aXI, 440p. 63 illus., 33 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _a-1. Lipid A structure (A. Silipo, A. Molinaro) -- 2. Structure of the lipopolysaccharide core region (O. Holst) -- 3. Structure of O-antigens (Y.A. Knirel) -- 4. Chemical synthesis of lipid A and analogues (S. Kusumoto) -- 5. Chemical synthesis of lipopolysaccharide core (P. Kosma, A. Zamyatina) -- 6. Genetics and biosynthesis of lipid A (C.M. Stead, A.C. Pride, M.S. Trent) -- 7. Pathways for the biosynthesis of NDP sugars (Y. Hao, J. Lam) -- 8. Lipopolysaccharide core oligosaccharide biosynthesis and assembly (U. Mamat, M. Skurnik, J.A. Bengoechea) -- 9. Genetics, biosynthesis and assembly of O-antigen (M.A. Valvano, S.E. Furlong, K.B. Patel) -- 10. Lipopolysaccharide export to the outer membrane (P. Sperandeo, G. Dehò, A. Polissi) -- 11. Evolution of lipopolysaccharide biosynthesis genes (M.M. Cunneen, P.R. Reeves) -- 12. The molecular basis of lipid A and Toll-like receptor 4 interactions (G.L. Hold, C.E. Bryant) -- 13. Modulation of lipopolysaccharide signalling through TLR4 agonists and antagonists (F. Peri, M. Piazza, V. Calabrese, R. Cighetti) -- 14. Lipopolysaccharide interactions with plants (G. Erbs, M.-A. Newman).
520 _aThe bacterial lipopolysaccharide also known as endotoxin is exhaustively covered in the present work. Central emphasis is placed upon the fine chemical structure of the lipopolysaccharide and its significance for understanding their activity and function. In particular, the role it plays in the interaction of bacteria with other biological systems is examined. New aspects of their physicochemical biology are introduced and updates to the current knowledge concerning the lipopolysaccharide are provided. This important class of biomolecules has recently attracted the attention of many investigators, in particular for understanding its involvement in innate immunity, toll-like receptor recognition and intracellular signaling.
650 0 _aChemistry.
650 0 _aImmunology.
650 0 _aToxicology.
650 0 _aMicrobiology.
650 0 _aCarbohydrates.
650 0 _aBiochemistry.
650 1 4 _aChemistry.
650 2 4 _aApplied Microbiology.
650 2 4 _aImmunology.
650 2 4 _aMedical Biochemistry.
650 2 4 _aCarbohydrate Chemistry.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aMedicinal Chemistry.
700 1 _aValvano, Miguel A.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783709107324
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-7091-0733-1
912 _aZDB-2-CMS
999 _c108691
_d108691