000 02826nam a22004815i 4500
001 978-3-642-22860-5
003 DE-He213
005 20140220083810.0
007 cr nn 008mamaa
008 110829s2011 gw | s |||| 0|eng d
020 _a9783642228605
_9978-3-642-22860-5
024 7 _a10.1007/978-3-642-22860-5
_2doi
050 4 _aQD415-436
072 7 _aPNN
_2bicssc
072 7 _aSCI013040
_2bisacsh
082 0 4 _a547
_223
100 1 _aWoolford, Jason A.
_eauthor.
245 1 4 _aThe Double [3+2] Photocycloaddition Reaction
_h[electronic resource] /
_cby Jason A. Woolford.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aXVI, 184 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Theses
505 0 _aIntroduction and background -- Discovery of the double [3+2] photocycloaddition -- A brief discussion on fenestranes -- Investigation of the double [3+2] photocycloaddition reaction for the synthesis of fenestranes -- Attempted synthesis of a “criss-cross” double [3+2] photocycloadduct -- Attempts toward the synthesis of alternative structures via the double[3+2] photocycloaddition -- Conclusion -- Experimental -- References -- Appendix I.
520 _aJason Woolford's thesis describes for the first time, a double [3+2] photocycloaddition of alkenes onto aromatic rings. Modern synthetic chemistry relies on the ability of researchers to uncover new and more efficient ways of creating highly complex structures. This work describes a novel, environmentally friendly photochemical step that converts in one pot, trivial starting materials into otherwise difficult to contruct fenstrane frameworks.  The rigid cores of these frameworks have significant potential in drug design. Moreover, the novelty of this work overtakes many other methods for the creation of chiral centres. No less than seven chiral centres are created in the photochemical step together with the formation of four carbon-carbon bonds  and multifused rings. Jason's innovative work has been the subject of several publications in peer-reviewed journals.
650 0 _aChemistry.
650 0 _aAnalytical biochemistry.
650 0 _aChemistry, Organic.
650 0 _aBiochemistry.
650 1 4 _aChemistry.
650 2 4 _aOrganic Chemistry.
650 2 4 _aMedicinal Chemistry.
650 2 4 _aAnalytical Chemistry.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642228599
830 0 _aSpringer Theses
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-22860-5
912 _aZDB-2-CMS
999 _c108269
_d108269