000 03002nam a22005175i 4500
001 978-3-642-22592-5
003 DE-He213
005 20140220083809.0
007 cr nn 008mamaa
008 110831s2011 gw | s |||| 0|eng d
020 _a9783642225925
_9978-3-642-22592-5
024 7 _a10.1007/978-3-642-22592-5
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
100 1 _aYakubovich, Alexander V.
_eauthor.
245 1 0 _aTheory of Phase Transitions in Polypeptides and Proteins
_h[electronic resource] /
_cby Alexander V. Yakubovich.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aXIV, 122 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Theses
505 0 _aIntroduction -- Theoretical Methods of Quantum Mechanics -- Degrees of Freedom in Polypeptides and Proteins -- Partition Function of a Polypeptide -- Phase Transitions in Polypeptides -- Folding of Proteins in Aqueous Environment.
520 _aThere are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.
650 0 _aPhysics.
650 0 _aPolymers.
650 0 _aBiochemistry.
650 0 _aMathematical physics.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aProtein Structure.
650 2 4 _aPhase Transitions and Multiphase Systems.
650 2 4 _aPolymer Sciences.
650 2 4 _aMathematical Methods in Physics.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642225918
830 0 _aSpringer Theses
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-22592-5
912 _aZDB-2-PHA
999 _c108223
_d108223