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001 978-3-642-19703-1
003 DE-He213
005 20140220083757.0
007 cr nn 008mamaa
008 110401s2011 gw | s |||| 0|eng d
020 _a9783642197031
_9978-3-642-19703-1
024 7 _a10.1007/978-3-642-19703-1
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aHagan, Jim J.
_eeditor.
245 1 0 _aMolecular and Functional Models in Neuropsychiatry
_h[electronic resource] /
_cedited by Jim J. Hagan.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2011.
300 _aXIV, 394 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Behavioral Neurosciences,
_x1866-3370 ;
_v7
505 0 _aFrom the contents: Preface -- Mouse mutagenesis and disease models for Neuropsychiatric disorders. - Drosophila as a model organism for the study of neuropsychiatric disorders -- Transgenic animal models of Huntington’s Disease -- Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges -- Animal Models of Depression: Molecular Perspectives.-Animal models of ADHD -- Mouse Models of Autism: Testing Hypotheses about Molecular Mechanisms -- Advances in animal models of drug addiction -- When the serotonin transporter gene meets adversity: The contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience -- Functional and Pharmacological MRI in understanding brain function at a systems level -- The pig as model animal for studying cognition and neurobehavioral disorders.
520 _aCommon neuropsychiatric diseases are associated with significant human and economic cost. The development of more effective treatments requires scientific progress on a broad front and animal models have a vital role to play in these advances, enabling exploration of the functional consequences of molecular changes at the cellular, systems and behavioural levels. This volume discusses some of the latest and most exciting advances in the field. The first five chapters consider developments in gene modification techniques, their applications in vivo across a variety of species and the latest work related to Schizophrenia, Huntington’s Disease and Major Depressive Disorder. Three chapters then focus on recent developments in Autism, Drug Dependence and Attention Deficit Hyperactivity Disorder. In the final four chapters consideration is given to the development of models in larger species and to emergent approaches, such as epigenetic regulation, gene X environment interactions and MRI as a tool for understanding the function of neuronal systems in non- human species, all of which are likely to play an increasingly important role in the scientific discourse related to neuropsychiatric diseases.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aNeurology.
650 0 _aPsychiatry.
650 0 _aPsychopharmacology.
650 0 _aAnimal behavior.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aMolecular Medicine.
650 2 4 _aPsychopharmacology.
650 2 4 _aPsychiatry.
650 2 4 _aNeurology.
650 2 4 _aBehavioural Sciences.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642197024
830 0 _aCurrent Topics in Behavioral Neurosciences,
_x1866-3370 ;
_v7
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-19703-1
912 _aZDB-2-SBL
999 _c107619
_d107619