000 02889nam a22005175i 4500
001 978-3-642-17575-6
003 DE-He213
005 20140220083751.0
007 cr nn 008mamaa
008 110502s2011 gw | s |||| 0|eng d
020 _a9783642175756
_9978-3-642-17575-6
024 7 _a10.1007/978-3-642-17575-6
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aTripathi, Onkar N.
_eeditor.
245 1 0 _aHeart Rate and Rhythm
_h[electronic resource] :
_bMolecular Basis, Pharmacological Modulation and Clinical Implications /
_cedited by Onkar N. Tripathi, Ursula Ravens, Michael C. Sanguinetti.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aXXII, 678p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aNormal Cardiac Rhythm and Pacemaker Activity -- Modeling of Rhythm in the Heart -- Cardiac Development and Anatomy -- Mechanisms of Acquired Arrhythmia -- Mechanisms of Inherited Arrhythmia -- Role of Specific Channels and Transporters in Arrhythmia -- Drugs and Cardiac Arrhythmia.
520 _aPathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aToxicology.
650 0 _aCardiology.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aHuman Physiology.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aCardiology.
700 1 _aRavens, Ursula.
_eeditor.
700 1 _aSanguinetti, Michael C.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642175749
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-17575-6
912 _aZDB-2-SBL
999 _c107273
_d107273