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001 978-3-642-17426-1
003 DE-He213
005 20140220083750.0
007 cr nn 008mamaa
008 110519s2011 gw | s |||| 0|eng d
020 _a9783642174261
_9978-3-642-17426-1
024 7 _a10.1007/978-3-642-17426-1
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
100 1 _aPetronis, Arturas.
_eeditor.
245 1 0 _aBrain, Behavior and Epigenetics
_h[electronic resource] /
_cedited by Arturas Petronis, Jonathan Mill.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aXVI, 320 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aEpigenetics and Human Health
505 0 _aPreface.- 1. Post-translational histone modifications and the neurobiology of psychosis -- 2. Epigenetic regulation of GABAergic targets in psychiatry -- 3. Possible roles of DNA methylation in bipolar disorder -- 4. The epigenetics of depression and suicide -- 5. Epidemiology research and epigenetics: Translational epidemiology of schizophrenia.-  6. Environmental studies as a tool for detecting epigenetic mechanisms in schizophrenia.- 7. Imprinting, inactivation and the behavioural genetics of the X-chromosome.-  8. The strategies of the genes: genomic conflicts, attachment theory and  development of the social brain -- 9. Genomic imprinting effects on brain and behavior; future directions -- 10. Epigenetic influence of the social environment -- 11. Towards an understanding of the dynamic inter-dependence of genes and environment in the regulation of phenotype.  Nurturing our epigenetic nature.- 12. Histone deacetylase inhibitors: a novel therapeutic approach for cognitive disorders.-  13. Epigenetic mechanisms of memory consolidation.-  14. Epigenetic mechanisms in memory formation -- Subject index.
520 _aDespite significant progress in molecular epigenetic research and its enormous potential, there are still considerable challenges to overcome before we can fully understand the role of epigenetic processes in brain function and behavior. For instance, what comprises a ‘normal’ brain epigenome and what is the degree of region- and cellular-specificity of epigenetic landscapes in the brain? How do the multiple layers of epigenetic information interact and change over time? How common is meiotic epigenetic heritability and what role it may play in complex psychiatric disease? To what extent is the epigenome plastic and malleable in response to environmental influences? This volume demonstrates that such questions can now be explored in an experimental molecular biology laboratory. While the community is only just starting to acknowledge the importance of epigenetic processes in the brain, there is no doubt that numerous breakthrough discoveries in brain and behavioral epigenetics will be made in the decades to come.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aPsychiatry.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aPsychiatry.
700 1 _aMill, Jonathan.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642174254
830 0 _aEpigenetics and Human Health
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-17426-1
912 _aZDB-2-SBL
999 _c107253
_d107253