000 02390nam a22004815i 4500
001 978-3-642-16931-1
003 DE-He213
005 20140220083750.0
007 cr nn 008mamaa
008 110201s2011 gw | s |||| 0|eng d
020 _a9783642169311
_9978-3-642-16931-1
024 7 _a10.1007/978-3-642-16931-1
_2doi
050 4 _aQD433-436
072 7 _aPSB
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572.84
_223
100 1 _aDavidovich, Chen.
_eauthor.
245 1 0 _aTargeting Functional Centers of the Ribosome
_h[electronic resource] /
_cby Chen Davidovich.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aXIV, 74 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Theses
505 0 _aIntroduction -- Methods -- Results -- Discussion.
520 _aThis thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
650 0 _aLife sciences.
650 0 _aChemistry, Organic.
650 0 _aNucleic acids.
650 0 _aBiochemistry.
650 1 4 _aLife Sciences.
650 2 4 _aNucleic Acid Chemistry.
650 2 4 _aProtein Science.
650 2 4 _aOrganic Chemistry.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642169304
830 0 _aSpringer Theses
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-16931-1
912 _aZDB-2-SBL
999 _c107214
_d107214