000 02856nam a22004815i 4500
001 978-3-642-16555-9
003 DE-He213
005 20140220083749.0
007 cr nn 008mamaa
008 110215s2011 gw | s |||| 0|eng d
020 _a9783642165559
_9978-3-642-16555-9
024 7 _a10.1007/978-3-642-16555-9
_2doi
050 4 _aQH573-671
072 7 _aPSF
_2bicssc
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
100 1 _aMecham, Robert P.
_eeditor.
245 1 4 _aThe Extracellular Matrix: an Overview
_h[electronic resource] /
_cedited by Robert P. Mecham.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aXIV, 426 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiology of Extracellular Matrix
505 0 _aAn overview of extracellular matrix structure and function --  Fibronectin and other adhesive glycoproteins --  Collagen: suprastructures and collagen fibril assembly.-  Asement membrane; Hyaluronan and the Aggregating Proteoglycans -- The small, leucine-rich proteoglycans -- Microfibrils and fibrillin -- Elastin -- Lysyl oxidase and lysyl oxidase-like enzymes -- The Fibulins -- Matricellular proteins.
520 _aKnowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment.  Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
650 0 _aLife sciences.
650 0 _aMedicine.
650 0 _aBiochemistry.
650 0 _aCytology.
650 1 4 _aLife Sciences.
650 2 4 _aCell Biology.
650 2 4 _aProtein Science.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642165542
830 0 _aBiology of Extracellular Matrix
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-16555-9
912 _aZDB-2-SBL
999 _c107166
_d107166