| 000 | 02532nam a22004455i 4500 | ||
|---|---|---|---|
| 001 | 978-3-642-15473-7 | ||
| 003 | DE-He213 | ||
| 005 | 20140220083747.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 110119s2011 gw | s |||| 0|eng d | ||
| 020 |
_a9783642154737 _9978-3-642-15473-7 |
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| 024 | 7 |
_a10.1007/978-3-642-15473-7 _2doi |
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| 050 | 4 | _aQD415-436 | |
| 072 | 7 |
_aPNN _2bicssc |
|
| 072 | 7 |
_aSCI013040 _2bisacsh |
|
| 082 | 0 | 4 |
_a547 _223 |
| 100 | 1 |
_aOhta, Yusuke. _eauthor. |
|
| 245 | 1 | 0 |
_aCopper-Catalyzed Multi-Component Reactions _h[electronic resource] : _bSynthesis of Nitrogen-Containing Polycyclic Compounds / _cby Yusuke Ohta. |
| 264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2011. |
|
| 300 |
_aXVI, 104 p. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 | _aSpringer Theses | |
| 520 | _aA copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers. | ||
| 650 | 0 | _aChemistry. | |
| 650 | 0 | _aChemistry, Organic. | |
| 650 | 0 | _aBiochemistry. | |
| 650 | 1 | 4 | _aChemistry. |
| 650 | 2 | 4 | _aOrganic Chemistry. |
| 650 | 2 | 4 | _aMedicinal Chemistry. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783642154720 |
| 830 | 0 | _aSpringer Theses | |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-642-15473-7 |
| 912 | _aZDB-2-CMS | ||
| 999 |
_c107059 _d107059 |
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