000 03384nam a22004935i 4500
001 978-3-642-14773-9
003 DE-He213
005 20140220083746.0
007 cr nn 008mamaa
008 101109s2011 gw | s |||| 0|eng d
020 _a9783642147739
_9978-3-642-14773-9
024 7 _a10.1007/978-3-642-14773-9
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
100 1 _aRousseaux, Sophie.
_eeditor.
245 1 0 _aEpigenetics and Human Reproduction
_h[electronic resource] /
_cedited by Sophie Rousseaux, Saadi Khochbin.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2011.
300 _aXVI, 372 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aEpigenetics and Human Health,
_x2191-2262
505 0 _aPreface – B. Jegou -- Part 1 - Medical aspects and questions raised on the molecular basis of epigenome involvement in reproduction -- Part 2 - Fundamental aspects of genome and epigenome reprogramming during gametogenesis -- Part 3 – Re-organization of nuclear compartments during gametogenesis -- Part 4 - Fundamental aspects of gene expression regulation during gametogenesis -- Subject index.
520 _aEpigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction. The book presents epigenetic transitions that are important at defined stages of gametogenesis and during meiosis. Several of the sixteen chapters written by experts in the field cover fundamental concepts discovered through cellular and biochemical work and from research on animal models. In other chapters, key examples are provided of how disruption of these mechanisms affects germ cell development and fertility, and contributes to the germinal cancers. Finally, the book discusses how in vitro manipulation and culture in assisted reproduction can epigenetically perturb germ cells, and how this can trigger disease phenotypes in the next generation. Conceived towards advanced students, medical professionals and research scientists, this is the first comprehensive textbook on this topic that will serve as a valuable reference during the years to come
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aReproductive Medicine.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aReproductive Medicine.
700 1 _aKhochbin, Saadi.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642147722
830 0 _aEpigenetics and Human Health,
_x2191-2262
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-14773-9
912 _aZDB-2-SBL
999 _c106988
_d106988