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001 978-3-642-14626-8
003 DE-He213
005 20140220083745.0
007 cr nn 008mamaa
008 101013s2011 gw | s |||| 0|eng d
020 _a9783642146268
_9978-3-642-14626-8
024 7 _a10.1007/978-3-642-14626-8
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aReinoso-Suárez, Fernando.
_eauthor.
245 1 0 _aFunctional Anatomy of the Sleep-Wakefulness Cycle: Wakefulness
_h[electronic resource] /
_cby Fernando Reinoso-Suárez, Isabel de Andrés, Miguel Garzón.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2011.
300 _aXII, 130p. 53 illus., 11 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Anatomy, Embryology and Cell Biology,
_x0301-5556 ;
_v208
505 0 _aThe sleep-wakefulness cycle -- Revision of the publications describing the anatomical connections and effects of lesions and electrical stimulation of brain structures on the sleep-wakefulness cycle -- The peripheral nerves and spinal cord -- Medullary and caudal pontine tegmentum -- Oral pontine tegmentum and superior cerebellar peduncle -- Midbrain tegmentum, hypothalmus and basal forebrain -- Thalamus -- Cerebral cortex -- Final commentary -- Functional anatomy of wakefulness -- The brainstem-hypothalamic wakefulness structures and their neurotransmitters -- Other brain structures with their neurotransmitters that participate in wakefulness -- Final commentary -- References -- Subject index.
520 _aWakefulness is a necessary, active and periodic brain state, with a circadian and homeostatic regulation and precisely meshed with other states into the sleep-wakefulness cycle. This monograph first overviews the historical background and current understanding of the neuronal systems generating and/or maintaining the various phases of the sleep-wakefulness cycle. A key cellular correlate of wakefulness is a sustained mode of high activity and plasticity in the closely intertwined circuits of the cortex and thalamus, the “thalamo-cerebral cortex unity”. The second part of the monograph provides an in-depth review of recent advances on the anatomy, physiology and neurochemistry of the neuronal groups known to drive the “thalamo-cerebral cortex unity” into their wakefulness mode, and to keep them in such mode. Interestingly, these neuronal groups are located in the brainstem, hypothalamus or basal forebrain; collectively, they are known as the “ascending reticular activating system”. Neurotransmitter-specific pathways arising from these neuronal groups target the thalamus and cortex. The various neurotransmitters interact on postsynaptic cortical or thalamic cells to fine-tune their excitability and plasticity, exerting powerful influences on the perceptual and cognitive processes as well as attentional, emotional, motivational, behavioral and arousal states. In turn, corticofugal axons reach the neuronal groups of the “ascending reticular activating system”, and thus the awake “thalamo-cerebral cortex unity” is in position to modulate their activity
650 0 _aMedicine.
650 0 _aNeurosciences.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
700 1 _ade Andrés, Isabel.
_eauthor.
700 1 _aGarzón, Miguel.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642146251
830 0 _aAdvances in Anatomy, Embryology and Cell Biology,
_x0301-5556 ;
_v208
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-14626-8
912 _aZDB-2-SME
999 _c106967
_d106967