000 03010nam a22005655i 4500
001 978-3-642-14541-4
003 DE-He213
005 20140220083745.0
007 cr nn 008mamaa
008 101120s2011 gw | s |||| 0|eng d
020 _a9783642145414
_9978-3-642-14541-4
024 7 _a10.1007/978-3-642-14541-4
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aFromm, Martin F.
_eeditor.
245 1 0 _aDrug Transporters
_h[electronic resource] /
_cedited by Martin F. Fromm, Richard B. Kim.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aX, 454 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v201
505 0 _aFrom the contents -- Preface -- Organic anion transporting polypeptides (OATPs); In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy; In vitro and in vivo evidence for the importance of organic cation transporters (OCTs, MATEs) in drug therapy; Intestinal bile salt transporters (ASBT and OST alpha/beta); hepatic bile salt transporters (NTCP and BSEP); Importance of P-glycoprotein for drug-drug interactions; Importance of the multidrug resistance protein (MRP) family for pathophysiology and drug therapy; Importance of breast cancer resistance protein transporters (BCRP); Molecular mechanisms of drug transporters regulation; In vivo probes of drug transport.
520 _aIt is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aDrug interactions.
650 0 _aToxicology.
650 0 _aPharmaceutical technology.
650 0 _aClinical medicine.
650 0 _aNephrology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aPharmaceutical Sciences/Technology.
650 2 4 _aHuman Physiology.
650 2 4 _aDrug Resistance.
650 2 4 _aHepatology.
650 2 4 _aNephrology.
700 1 _aKim, Richard B.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642145407
830 0 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v201
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-14541-4
912 _aZDB-2-SBL
999 _c106961
_d106961