000 02735nam a22004455i 4500
001 978-3-642-14136-2
003 DE-He213
005 20140220083745.0
007 cr nn 008mamaa
008 110411s2011 gw | s |||| 0|eng d
020 _a9783642141362
_9978-3-642-14136-2
024 7 _a10.1007/978-3-642-14136-2
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aDranoff, Glenn.
_eeditor.
245 1 0 _aCancer Immunology and Immunotherapy
_h[electronic resource] /
_cedited by Glenn Dranoff.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aXIV, 306 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v344
520 _aThe recent FDA approval of Provenge® as the first therapeutic cancer vaccine together with the recent demonstration that Ipilimumab®, a monoclonal antibody that blocks the negative immune checkpoint cytotoxic T lymphocyte associated antigen-4, prolongs patient survival are major achievements that usher in a new era of cancer immunotherapy. These “first-in-class” treatments reflect the substantive progress that basic and translational scientists have made towards understanding the mechanisms underlying protective tumor immunity in cancer patients Immunotherapies were first explored at the turn of the twentieth century, but the crafting of potent treatments required more detailed knowledge of how the immune system responds to cancer. Advances in genetic, cellular, and biochemical technologies have begun to yield this critical information, focusing attention on immune recognition, regulation, and escape. Indeed, the dynamic interplay of these processes in the tumor microenvironment is now recognized to play a decisive role in determining disease outcome. This volume highlights the rapid progress and breadth of research in cancer immunology, and provides a framework for anticipating many more clinical successes in cancer immunotherapy.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aImmunology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aImmunology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642141355
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v344
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-14136-2
912 _aZDB-2-SBL
999 _c106934
_d106934