000 02674nam a22004215i 4500
001 978-3-540-89891-7
003 DE-He213
005 20140220083740.0
007 cr nn 008mamaa
008 101224s2011 gw | s |||| 0|eng d
020 _a9783540898917
_9978-3-540-89891-7
024 7 _a10.1007/978-3-540-89891-7
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aVogel, Hans Gerhard.
_eeditor.
245 1 0 _aDrug Discovery and Evaluation: Methods in Clinical Pharmacology
_h[electronic resource] /
_cedited by Hans Gerhard Vogel, Jochen Maas, Alexander Gebauer.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2011.
300 _aXII, 564p. 138 illus.. eReference.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
520 _aDrug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
650 0 _aMedicine.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
700 1 _aMaas, Jochen.
_eeditor.
700 1 _aGebauer, Alexander.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540898900
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-540-89891-7
912 _aZDB-2-SBL
999 _c106678
_d106678