000			02658nam a22004815i 4500
001			978-3-0348-0157-7
003			DE-He213
005			20140220083739.0
007			cr nn 008mamaa
008			110801s2011 sz | s |||| 0|eng d
020			_a9783034801577 _9978-3-0348-0157-7
024	7		_a10.1007/978-3-0348-0157-7 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
100	1		_aVergnolle, Nathalie. _eeditor.
245	1	0	_aProteases and Their Receptors in Inflammation _h[electronic resource] / _cedited by Nathalie Vergnolle, Michel Chignard.
264		1	_aBasel : _bSpringer Basel, _c2011.
300			_aXIV, 310 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProgress in Inflammation Research
520			_aProteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest.  In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response. This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aEmerging infectious diseases.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aCell Biology.
650	2	4	_aInfectious Diseases.
700	1		_aChignard, Michel. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783034801560
830		0	_aProgress in Inflammation Research
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-0348-0157-7
912			_aZDB-2-SME
999			_c106607 _d106607