000			03315nam a22005535i 4500
001			978-3-0348-0148-5
003			DE-He213
005			20140220083739.0
007			cr nn 008mamaa
008			110630s2011 sz | s |||| 0|eng d
020			_a9783034801485 _9978-3-0348-0148-5
024	7		_a10.1007/978-3-0348-0148-5 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
100	1		_aCouillin, Isabelle. _eeditor.
245	1	4	_aThe Inflammasomes _h[electronic resource] / _cedited by Isabelle Couillin, Virginie Pétrilli, Fabio Martinon.
264		1	_aBasel : _bSpringer Basel, _c2011.
300			_aXIV, 226 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProgress in Inflammation Research
505	0		_aMolecular definition of inflammasomes -- Pyroptosis: A Caspase-1-dependent programmed cell death and a barrier to infection -- Activation of the inflammasome by bacterial pathogens -- The Role of Inflammasomes in Viral Infection -- Inflammasome activation in response to eukaryotic pathogens -- Inflammasome activation by pathogenic crystals and particles -- Inflammasome activation by danger signals -- Toll like receptors and inflammasomes -- Inflammasome in the skin -- Cancer, inflammasomes and adjuvanticity -- Inflammasome and lung pathologies -- Mechanisms of NLRP3 inflammasome activation in CAPS patients -- Activation and regulation of the NLRP3 inflammasome -- Treatment of inflammasome-related disorders.
520			_aThe inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aEmerging infectious diseases.
650		0	_aEnzymes.
650		0	_aCytokines.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aInfectious Diseases.
650	2	4	_aCell Biology.
650	2	4	_aCytokines and Growth Factors.
650	2	4	_aEnzymology.
700	1		_aPétrilli, Virginie. _eeditor.
700	1		_aMartinon, Fabio. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783034801478
830		0	_aProgress in Inflammation Research
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-0348-0148-5
912			_aZDB-2-SME
999			_c106606 _d106606