000 03968nam a22005415i 4500
001 978-3-0346-0277-8
003 DE-He213
005 20140220083738.0
007 cr nn 008mamaa
008 101109s2011 sz | s |||| 0|eng d
020 _a9783034602778
_9978-3-0346-0277-8
024 7 _a10.1007/978-3-0346-0277-8
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
100 1 _aDormitzer, Philip R.
_eeditor.
245 1 0 _aReplicating Vaccines
_h[electronic resource] :
_bA New Generation /
_cedited by Philip R. Dormitzer, Christian W. Mandl, Rino Rappuoli.
250 _aFirst.
264 1 _aBasel :
_bSpringer Basel,
_c2011.
300 _aXIII, 447 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBirkhäuser Advances in Infectious Diseases
505 0 _aSECTION 1: Today’s Live Attenuated Vaccines -- Live Vaccines and their Role in Modern Vaccinology -- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster -- Classical Live Viral Vaccines -- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines -- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus -- Live Attenuated Shigella Vaccines. Is encouraging good enough? -- New generation BCG vaccines -- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines -- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines -- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches -- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread -- RSV Deletion Mutant – Innate Immunity -- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity -- SECTION 4: New Types of Replicating Vaccines -- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors -- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines -- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines -- Alphavirus Particle-based Vaccine Vectors -- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses.
520 _aTechnological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMicrobiology.
650 0 _aVaccines.
650 0 _aMedical virology.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
650 2 4 _aVaccine.
650 2 4 _aImmunology.
650 2 4 _aVirology.
700 1 _aMandl, Christian W.
_eeditor.
700 1 _aRappuoli, Rino.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783034602761
830 0 _aBirkhäuser Advances in Infectious Diseases
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-0346-0277-8
912 _aZDB-2-SBL
999 _c106571
_d106571