000			03174nam a22004935i 4500
001			978-1-908517-28-9
003			DE-He213
005			20140220083737.0
007			cr nn 008mamaa
008			131217s2011 xxk| s |||| 0|eng d
020			_a9781908517289 _9978-1-908517-28-9
024	7		_a10.1007/978-1-908517-28-9 _2doi
050		4	_aRC681-688.2
072		7	_aMJD _2bicssc
072		7	_aMED010000 _2bisacsh
082	0	4	_a616.12 _223
100	1		_aNeutel, Joel M. _eauthor.
245	1	0	_aCombination Therapy in Hypertension _h[electronic resource] / _cby Joel M. Neutel.
264		1	_aTarporley : _bSpringer Healthcare Ltd. : _bImprint: Springer Healthcare, _c2011.
300			_aVII, 84 p. 43 illus., 3 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_a1. State of Hypertension Control in 2007 -- 2. Historical Review of Combination Therapy -- 3. Advantages of Combination Therapy and Monotherapy -- 4. Use of Combination Therapy and Monotherapy -- 5. Outcome Studies with Combination Therapy -- 6. USe of Combination Therapy as First Line Treatment -- 7. Available Combination Agents.
520			_aFor over 30 years, the stepped care approach has been used in the management and treatment of hypertension. This approach advocates the use of initial monotherapy to reach the desired blood pressure, and the subsequent use of additional drugs with complementary modes of action, until the target BP is achieved. However, current control rates for hypertension suggest that such an approach may be outdated and no longer effective in the management of hypertension. Clinical trials have shown that more than 50% of patients require a combination of drug therapies to achieve their target BP. Some proponents of combination therapy have argued that the risk of adverse side effects and non-compliance will be lower than that compared to monotherapy, which initially requires higher doses to be administered to be effective. Consequently, there have been increasing calls of the necessity for a much more combined approach in the treatment of hypertension. Adding to this, Combination Therapy in Hypertension will cover current control rates of blood pressure worldwide, the benefits of monotherapy and combination therapy, examine the effectiveness, risk of adverse effects, compliance, and cost of the available therapies and will also include information on relevant outcome studies.
650		0	_aMedicine.
650		0	_aFamily medicine.
650		0	_aAngiography.
650		0	_aCardiology.
650		0	_aEmergency medicine.
650	1	4	_aMedicine & Public Health.
650	2	4	_aCardiology.
650	2	4	_aPharmacotherapy.
650	2	4	_aPrimary Care Medicine.
650	2	4	_aAngiology.
650	2	4	_aGeneral Practice / Family Medicine.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781908517258
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-908517-28-9
912			_aZDB-2-SME
999			_c106509 _d106509