000			03307nam a22005055i 4500
001			978-1-84882-644-1
003			DE-He213
005			20140220083736.0
007			cr nn 008mamaa
008			110331s2011 xxk| s |||| 0|eng d
020			_a9781848826441 _9978-1-84882-644-1
024	7		_a10.1007/978-1-84882-644-1 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
100	1		_aRoach, Helmtrud I. _eeditor.
245	1	0	_aEpigenetic Aspects of Chronic Diseases _h[electronic resource] / _cedited by Helmtrud I. Roach, Felix Bronner, Richard O.C. Oreffo.
264		1	_aLondon : _bSpringer London : _bImprint: Springer, _c2011.
300			_aXVIII, 238p. 48 illus., 42 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aEpigenetics and Chronic Diseases: An Overview -- Techniques to Study DNA Methylation and Histone Modification -- Mechanisms of Epigenetic Gene Silencing -- Mechanisms of Epigenetic Gene Activation in Disease: Dynamics of DNA Methylation and Demethylation -- The Role of Histone Demethylases in Disease -- Autoimmune Diseases -- Epigenetics of Rheumatoid Arthritis -- DNA Methylation Changes in Osteoarthritis -- Epigenetics and Type 2 Diabetes -- Epigenetic Regulation of Asthma and Allergic Diseases -- Epigenetics in Psychiatry -- Epigenetics and Late-Onset Alzheimer’s Disease -- Epigenetic Mechanisms in the Developmental Origins of Adult Disease -- Targeting Histone Deacetylases in Chronic Obstructive Pulmonary Disease -- Clinical Trials of Epigenetic Modifiers in the Treatment of Myelodysplastic Syndrome.
520			_aEpigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aInternal medicine.
650		0	_aBiochemistry.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aMedical Biochemistry.
650	2	4	_aInternal Medicine.
700	1		_aBronner, Felix. _eeditor.
700	1		_aOreffo, Richard O.C. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781848826434
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-84882-644-1
912			_aZDB-2-SBL
999			_c106437 _d106437