000 03556nam a22004455i 4500
001 978-1-61779-304-2
003 DE-He213
005 20140220083736.0
007 cr nn 008mamaa
008 110829s2011 xxu| s |||| 0|eng d
020 _a9781617793042
_9978-1-61779-304-2
024 7 _a10.1007/978-1-61779-304-2
_2doi
050 4 _aQH301-705
072 7 _aPSA
_2bicssc
072 7 _aSCI086000
_2bisacsh
082 0 4 _a570
_223
100 1 _aRovensky, Yury A.
_eauthor.
245 1 0 _aAdhesive Interactions in Normal and Transformed Cells
_h[electronic resource] /
_cby Yury A. Rovensky.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2011.
300 _aXX, 225p. 134 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- The Extracellular Matrix -- Cytoskeleton -- Pseudopodia and Adhesion Structures -- Adhesive Interactions of Tissue Cells with the Extracellular Matrix -- Cell Migration -- Cell Responses to Chemical Heterogeneity of Substrata: Adhesive “Islets” or  “Paths” -- Topographic Cell Responses -- Intercellular Adhesive Interactions -- Conclusions.
520 _aAdhesive Interactions in Normal and Transformed Cells describes the basic mechanisms of the ability of tissue cells to attach to each other and to the extracellular matrix. These adhesive interactions are pivotal regulators of main cellular functions, such as proliferation, survival and migration. The adhesive interactions are involved in embryonic development, regeneration, and also in inflammation and degeneration processes, which are at the basis of many diseases. Serious alterations in cell adhesion caused by the oncogenic transformation play a key role in cancer invasion and metastasis. This volume provides comprehensive information about structural, mechanistic and signaling aspects of adhesive interactions in both normal and cancer cells in comparison. Integration of such aspects of the adhesive process as structure, relation to cell systems of receptors and cytoskeleton, function, signaling pathways, and the alterations in tumor cells constitutes the strongest point of this work. The results of the long-time author’s research are included in the book. The author was one of pioneers, who used scanning electron microscopy (SEM) to study the cell surface morphology of normal cultured cells and the cells underwent the oncogenic transformation, processes of their attachment to and spreading on the surfaces of a solid substratum, and also surprising ability of the cells to respond to various geometric configurations of the substrata surfaces.  Adhesive Interactions in Normal and Transformed Cells has both biological and medical aspects and, therefore, it can be interesting not only for cell biologists, developmental biologists and cancer researchers, but also for physicians. It is intended for researchers, postdocs, undergraduate and graduate students.
650 0 _aLife sciences.
650 0 _aOncology.
650 0 _aCytology.
650 1 4 _aLife Sciences.
650 2 4 _aLife Sciences, general.
650 2 4 _aCancer Research.
650 2 4 _aCell Physiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781617793035
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-61779-304-2
912 _aZDB-2-SBL
999 _c106418
_d106418