| 000 | 02672nam a22004575i 4500 | ||
|---|---|---|---|
| 001 | 978-1-61737-995-6 | ||
| 003 | DE-He213 | ||
| 005 | 20140220083735.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 110302s2011 xxu| s |||| 0|eng d | ||
| 020 |
_a9781617379956 _9978-1-61737-995-6 |
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| 024 | 7 |
_a10.1007/978-1-61737-995-6 _2doi |
|
| 050 | 4 | _aRC261-271 | |
| 072 | 7 |
_aMJCL _2bicssc |
|
| 072 | 7 |
_aMED062000 _2bisacsh |
|
| 082 | 0 | 4 |
_a614.5999 _223 |
| 100 | 1 |
_aPenning, Trevor M. _eeditor. |
|
| 245 | 1 | 0 |
_aChemical Carcinogenesis _h[electronic resource] / _cedited by Trevor M. Penning. |
| 250 | _a1. | ||
| 264 | 1 |
_aTotowa, NJ : _bHumana Press, _c2011. |
|
| 300 |
_aXVI, 440 p. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 | _aCurrent Cancer Research | |
| 520 | _aThis monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code. It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aOncology. | |
| 650 | 0 | _aToxicology. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aCancer Research. |
| 650 | 2 | 4 | _aPharmacology/Toxicology. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781617379949 |
| 830 | 0 | _aCurrent Cancer Research | |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-61737-995-6 |
| 912 | _aZDB-2-SME | ||
| 999 |
_c106404 _d106404 |
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